Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes

Salvatore De Cosmo, Maria Chiara Rossi, Fabio Pellegrini, Giuseppe Lucisano, Simonetta Bacci, Sandro Gentile, Antonio Ceriello, Giuseppina Russo, Antonio Nicolucci, Carlo Giorda, Francesca Viazzi, Roberto Pontremoli

Research output: Contribution to journalArticlepeer-review

Abstract

BackgroundKidney dysfunction is a strong predictor of end-stage renal disease and cardiovascular (CV) events. The main goal was to study the clinical correlates of diabetic kidney disease in a large cohort of patients with type 2 diabetes mellitus (T2DM) attending 236 Diabetes Clinics in Italy.MethodsClinical data of 120 903 patients were extracted from electronic medical records by means of an ad hoc-developed software. Estimated glomerular filtration rate (GFR) and increased urinary albumin excretion were considered. Factors associated with the presence of albuminuria only, GFR <60 mL/min/1.73 m 2 only or both conditions were evaluated through multivariate analysis.ResultsMean age of the patients was 66.6 ± 11.0 years, 58.1% were male and mean duration of diabetes was 11.1 ± 9.4 years. The frequency of albuminuria, low GFR and both albuminuria and low GFR was 36.0, 23.5 and 12.2%, respectively. Glycaemic control was related to albuminuria more than to low GFR, while systolic and pulse pressure showed a trend towards higher values in patients with normal kidney function compared with those with both albuminuria and low GFR. Multivariate logistic analysis showed that age and duration of disease influenced both features of kidney dysfunction. Male gender was associated with an increased risk of albuminuria. Higher systolic blood pressure levels were associated with albuminuria, with a 4% increased risk of simultaneously having albuminuria and low GFR for each 5 mmHg increase.ConclusionsIn this large cohort of patients with T2DM, reduced GFR and increased albuminuria showed, at least in part, different clinical correlates. A worse CV risk profile is associated with albuminuria more than with isolated low GFR.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalNephrology Dialysis Transplantation
Volume29
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Albuminuria
  • Epidemiology
  • Type 2 diabetes

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Medicine(all)

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