Kidney failure stabilizes after an increase over 2 decades

Paolo Cravedi, Piero Ruggenenti, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review


The level of proteinuria is one of the most important predictors for progressive renal function loss in kidney disease. Reduction of urinary protein levels by renin-angiotensin-system (RAS) inhibitors limits renal function decline in patients with non-diabetic and diabetic nephropathies to the point that remission of the disease and regression of renal lesions have been reported. The increasing use of these drugs is possibly at the basis of the stabilization of rates of new cases of kidney failure reported to the US Renal Data System after a 2-decade period of progressive increases. RAS inhibition, however, may not be effective to the same degree in all patients. For those patients who do not reach a complete remission of proteinuria, treatment procedures to implement renoprotection should include strict blood pressure control (and metabolic control in diabetics), lowering of blood lipids, and lifestyle modifications. Early intervention may be important to maximize renoprotection, especially in diabetics.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalJournal of Renal Care
Issue number3
Publication statusPublished - Jul 2007


  • ACE inhibitor
  • Angiotensin receptor antagonist
  • Kidney failure
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology
  • Advanced and Specialised Nursing


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