Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation

G. Remuzzi; M. Rossini; O. Imberti; N. Perico; G. Remuzzi; N. Perico

doi:10.1016/0140-6736(91)91368-5

Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation

G. Remuzzi, M. Rossini, O. Imberti, N. Perico, G. Remuzzi, N. Perico

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Isolated glomeruli from Brown-Norway (RT1ⁿ) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT1¹) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2·5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT1¹) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

Original language	English
Pages (from-to)	750-752
Number of pages	3
Journal	Lancet
Volume	337
Issue number	8744
DOIs	https://doi.org/10.1016/0140-6736(91)91368-5
Publication status	Published - Mar 30 1991

ASJC Scopus subject areas

Medicine(all)

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10.1016/0140-6736(91)91368-5

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title = "Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation",

abstract = "Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT11) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2·5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT11) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.",

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T1 - Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation

AU - Remuzzi, G.

AU - Rossini, M.

AU - Imberti, O.

AU - Perico, N.

AU - Remuzzi, G.

AU - Perico, N.

PY - 1991/3/30

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N2 - Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT11) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2·5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT11) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

AB - Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT11) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2·5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT11) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

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Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation

Abstract

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