Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation

G. Remuzzi, M. Rossini, O. Imberti, N. Perico, G. Remuzzi, N. Perico

Research output: Contribution to journalArticlepeer-review

Abstract

Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT11) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2·5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT11) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

Original languageEnglish
Pages (from-to)750-752
Number of pages3
JournalLancet
Volume337
Issue number8744
DOIs
Publication statusPublished - Mar 30 1991

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation'. Together they form a unique fingerprint.

Cite this