Kidney instant monitoring (K.IN.G®)

A new analyzer to monitor kidney function

P. Caironi, T. Langer, P. Taccone, P. Bruzzone, S. De Chiara, F. Vagginelli, L. Caspani, C. Marenghi, L. Gattinoni

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim. The key role of the kidney in the regulation of body fluids and acid-base status is well known. Nonetheless, urine analysis has not received great attention in critically ill patients, likely due to the common practice of only analyzing 24-hour collected specimens. We hypothesized that the kidney may react more rapidly to minimal hemodynamic and acid-base status variations than can be assessed by a 24-hour analysis. Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis. Methods. A novel analyzer (Kidney INstant monitorinG-K.IN.G®) was developed that allows non-invasive, quasicontinuous analysis of urine pH, sodium, chloride, potassium and ammonium levels. Analytic measurement accuracy was calculated for urine samples of patients admitted to ICUs as well as medical staff, using standard techniques as references. For clinical investigation, approximately 200 patients were connected to the analyzer after ICU admission until discharge. Clinically relevant parameters were recorded. Here, three cases are presented. Results. For each analytic parameter, the accuracy of measurements obtained with the K.IN.G® analyzer appeared to be acceptable as compared to those of the reference techniques. In case 1, urine analysis revealed increased urinary sodium and chloride excretion strictly in parallel with mean arterial pressure, and increased ammonium excretion which was associated with moderate hypercapnia. Case 2 showed increases in urinary pH and sodium and chloride levels following awakening after sedation suspension. In case 3, urine analysis revealed an impairment of renal oncentrativepower, which was associated with hypovolemia. Conclusion. The K.IN.G® analyzer, allowing quasi-continuous monitoring of urinary pH and principal electrolyte levels, may represent a novel tool for clinical and research purposes.

Original languageEnglish
Pages (from-to)316-324
Number of pages9
JournalMinerva Anestesiologica
Volume76
Issue number5
Publication statusPublished - May 2010

Fingerprint

Urine
Kidney
Sodium Chloride
Ammonium Compounds
Hypovolemia
Acids
Hypercapnia
Medical Staff
Body Fluids
Critical Illness
Electrolytes
Suspensions
Potassium
Arterial Pressure
Hemodynamics
Research

Keywords

  • Kidney-monitoring
  • Physiologic-acid-base equilibrium

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Caironi, P., Langer, T., Taccone, P., Bruzzone, P., De Chiara, S., Vagginelli, F., ... Gattinoni, L. (2010). Kidney instant monitoring (K.IN.G®): A new analyzer to monitor kidney function. Minerva Anestesiologica, 76(5), 316-324.

Kidney instant monitoring (K.IN.G®) : A new analyzer to monitor kidney function. / Caironi, P.; Langer, T.; Taccone, P.; Bruzzone, P.; De Chiara, S.; Vagginelli, F.; Caspani, L.; Marenghi, C.; Gattinoni, L.

In: Minerva Anestesiologica, Vol. 76, No. 5, 05.2010, p. 316-324.

Research output: Contribution to journalArticle

Caironi, P, Langer, T, Taccone, P, Bruzzone, P, De Chiara, S, Vagginelli, F, Caspani, L, Marenghi, C & Gattinoni, L 2010, 'Kidney instant monitoring (K.IN.G®): A new analyzer to monitor kidney function', Minerva Anestesiologica, vol. 76, no. 5, pp. 316-324.
Caironi P, Langer T, Taccone P, Bruzzone P, De Chiara S, Vagginelli F et al. Kidney instant monitoring (K.IN.G®): A new analyzer to monitor kidney function. Minerva Anestesiologica. 2010 May;76(5):316-324.
Caironi, P. ; Langer, T. ; Taccone, P. ; Bruzzone, P. ; De Chiara, S. ; Vagginelli, F. ; Caspani, L. ; Marenghi, C. ; Gattinoni, L. / Kidney instant monitoring (K.IN.G®) : A new analyzer to monitor kidney function. In: Minerva Anestesiologica. 2010 ; Vol. 76, No. 5. pp. 316-324.
@article{a26806ac92b3466d9ce25e172675f57d,
title = "Kidney instant monitoring (K.IN.G{\circledR}): A new analyzer to monitor kidney function",
abstract = "Aim. The key role of the kidney in the regulation of body fluids and acid-base status is well known. Nonetheless, urine analysis has not received great attention in critically ill patients, likely due to the common practice of only analyzing 24-hour collected specimens. We hypothesized that the kidney may react more rapidly to minimal hemodynamic and acid-base status variations than can be assessed by a 24-hour analysis. Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis. Methods. A novel analyzer (Kidney INstant monitorinG-K.IN.G{\circledR}) was developed that allows non-invasive, quasicontinuous analysis of urine pH, sodium, chloride, potassium and ammonium levels. Analytic measurement accuracy was calculated for urine samples of patients admitted to ICUs as well as medical staff, using standard techniques as references. For clinical investigation, approximately 200 patients were connected to the analyzer after ICU admission until discharge. Clinically relevant parameters were recorded. Here, three cases are presented. Results. For each analytic parameter, the accuracy of measurements obtained with the K.IN.G{\circledR} analyzer appeared to be acceptable as compared to those of the reference techniques. In case 1, urine analysis revealed increased urinary sodium and chloride excretion strictly in parallel with mean arterial pressure, and increased ammonium excretion which was associated with moderate hypercapnia. Case 2 showed increases in urinary pH and sodium and chloride levels following awakening after sedation suspension. In case 3, urine analysis revealed an impairment of renal oncentrativepower, which was associated with hypovolemia. Conclusion. The K.IN.G{\circledR} analyzer, allowing quasi-continuous monitoring of urinary pH and principal electrolyte levels, may represent a novel tool for clinical and research purposes.",
keywords = "Kidney-monitoring, Physiologic-acid-base equilibrium",
author = "P. Caironi and T. Langer and P. Taccone and P. Bruzzone and {De Chiara}, S. and F. Vagginelli and L. Caspani and C. Marenghi and L. Gattinoni",
year = "2010",
month = "5",
language = "English",
volume = "76",
pages = "316--324",
journal = "Minerva Anestesiologica",
issn = "0375-9393",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "5",

}

TY - JOUR

T1 - Kidney instant monitoring (K.IN.G®)

T2 - A new analyzer to monitor kidney function

AU - Caironi, P.

AU - Langer, T.

AU - Taccone, P.

AU - Bruzzone, P.

AU - De Chiara, S.

AU - Vagginelli, F.

AU - Caspani, L.

AU - Marenghi, C.

AU - Gattinoni, L.

PY - 2010/5

Y1 - 2010/5

N2 - Aim. The key role of the kidney in the regulation of body fluids and acid-base status is well known. Nonetheless, urine analysis has not received great attention in critically ill patients, likely due to the common practice of only analyzing 24-hour collected specimens. We hypothesized that the kidney may react more rapidly to minimal hemodynamic and acid-base status variations than can be assessed by a 24-hour analysis. Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis. Methods. A novel analyzer (Kidney INstant monitorinG-K.IN.G®) was developed that allows non-invasive, quasicontinuous analysis of urine pH, sodium, chloride, potassium and ammonium levels. Analytic measurement accuracy was calculated for urine samples of patients admitted to ICUs as well as medical staff, using standard techniques as references. For clinical investigation, approximately 200 patients were connected to the analyzer after ICU admission until discharge. Clinically relevant parameters were recorded. Here, three cases are presented. Results. For each analytic parameter, the accuracy of measurements obtained with the K.IN.G® analyzer appeared to be acceptable as compared to those of the reference techniques. In case 1, urine analysis revealed increased urinary sodium and chloride excretion strictly in parallel with mean arterial pressure, and increased ammonium excretion which was associated with moderate hypercapnia. Case 2 showed increases in urinary pH and sodium and chloride levels following awakening after sedation suspension. In case 3, urine analysis revealed an impairment of renal oncentrativepower, which was associated with hypovolemia. Conclusion. The K.IN.G® analyzer, allowing quasi-continuous monitoring of urinary pH and principal electrolyte levels, may represent a novel tool for clinical and research purposes.

AB - Aim. The key role of the kidney in the regulation of body fluids and acid-base status is well known. Nonetheless, urine analysis has not received great attention in critically ill patients, likely due to the common practice of only analyzing 24-hour collected specimens. We hypothesized that the kidney may react more rapidly to minimal hemodynamic and acid-base status variations than can be assessed by a 24-hour analysis. Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis. Methods. A novel analyzer (Kidney INstant monitorinG-K.IN.G®) was developed that allows non-invasive, quasicontinuous analysis of urine pH, sodium, chloride, potassium and ammonium levels. Analytic measurement accuracy was calculated for urine samples of patients admitted to ICUs as well as medical staff, using standard techniques as references. For clinical investigation, approximately 200 patients were connected to the analyzer after ICU admission until discharge. Clinically relevant parameters were recorded. Here, three cases are presented. Results. For each analytic parameter, the accuracy of measurements obtained with the K.IN.G® analyzer appeared to be acceptable as compared to those of the reference techniques. In case 1, urine analysis revealed increased urinary sodium and chloride excretion strictly in parallel with mean arterial pressure, and increased ammonium excretion which was associated with moderate hypercapnia. Case 2 showed increases in urinary pH and sodium and chloride levels following awakening after sedation suspension. In case 3, urine analysis revealed an impairment of renal oncentrativepower, which was associated with hypovolemia. Conclusion. The K.IN.G® analyzer, allowing quasi-continuous monitoring of urinary pH and principal electrolyte levels, may represent a novel tool for clinical and research purposes.

KW - Kidney-monitoring

KW - Physiologic-acid-base equilibrium

UR - http://www.scopus.com/inward/record.url?scp=77954677400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954677400&partnerID=8YFLogxK

M3 - Article

VL - 76

SP - 316

EP - 324

JO - Minerva Anestesiologica

JF - Minerva Anestesiologica

SN - 0375-9393

IS - 5

ER -