Kidney involvement in medium- and large-vessel vasculitis

Federica Maritati, Francesco Iannuzzella, Maria P. Pavia, Sonia Pasquali, Augusto Vaglio

Research output: Contribution to journalReview article

Abstract

Medium- and large-vessel vasculitides (MVV and LVV, respectively) comprise a heterogeneous group of disorders whose common denominator is the inflammatory involvement of vessels of medium and large size. This disease spectrum includes giant-cell arteritis and Takayasu’s arteritis, which typically affect the aorta and its main branches, and Kawasaki’s disease and polyarteritis nodosa, which involve medium-sized arteries. Chronic periaortitis, characterized by a perivascular fibro-inflammatory reaction affecting the abdominal aorta and the periaortic tissue, frequently has a systemic distribution, involving other segments of the aorta and its major branches, and could thus be included in this group. Unlike small-vessel vasculitides, MVV and LVV do not cause glomerulonephritis, although glomerular immune-mediated lesions and tubulo-interstitial nephritis occur with varying frequency. However, MVV and LVV can often involve the renal artery and its branches, causing a wide array of lesions that range from renal artery stenosis to intra-renal vasculitis causing renal ischaemia/infarction, microaneurysms and haemorrhage. This review focuses on renal involvement in MVV and LVV and underlines why renal abnormalities in these syndromes should not be overlooked.

Original languageEnglish
Pages (from-to)495-505
Number of pages11
JournalJournal of Nephrology
Volume29
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Giant-cell arteritis
  • IgG4
  • Periaortitis
  • Polyarteritis nodosa
  • Renal artery stenosis
  • Renal infarction
  • Retroperitoneal fibrosis
  • Takayasu arteritis

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Maritati, F., Iannuzzella, F., Pavia, M. P., Pasquali, S., & Vaglio, A. (2016). Kidney involvement in medium- and large-vessel vasculitis. Journal of Nephrology, 29(4), 495-505. https://doi.org/10.1007/s40620-016-0303-8