IL TRAPIANTO DI RENE-PANCREAS. RESULTATI CLINICI SU 23 PAZIENTI CONSECUTIVI.

Translated title of the contribution: Kidney-pancreas transplantation: 23 consecutive cases.

M. Maestri, N. Krieger, P. Kuo, D. C. Dafoe, E. J. Alfrey

Research output: Contribution to journalArticlepeer-review

Abstract

Immunosuppressive approaches to combined kidney-pancreas tx include quadruple therapy with either antilymphocyte globulin (ATG) or OKT3 for a short period (7-14 days) immediately after transplantation. Maintenance therapy with prednisone, azathioprine and cyclosporin is then used to ensure the long-term survival of the graft. This study reports 23 cases of combined kidney-pancreas tx under ATG induction (n = 7) and OKT3 induction (n = 16). Both groups had maintenance therapy with azathioprine, prednisone and cyclosporin. The follow-up was 12 months. Graft loss was 3 out of 7 vs 1 out of 16 (p <0.05) for the kidney and 3 out of 7 vs 3 out of 16 for the pancreas in ATG treated vs OKT3 treated patients respectively. There were two deaths in the ATG group and one in the OKT3 group; two patients died with functioning graft, one in each group. The one year actuarial survival was 87% for graft and patient, 83% for kidney and 77% for pancreas. Combined kidney-pancreas tx with ATG or OKT3 have a similar outcome. OKT3 allows a longer period before the onset of rejection. There is a trend in survivals which suggests a better survival in OKT3 treated recipients. Infections and other complications were similar in ATG and OKT3 patients.

Translated title of the contributionKidney-pancreas transplantation: 23 consecutive cases.
Original languageItalian
Pages (from-to)121-128
Number of pages8
JournalMinerva Chirurgica
Volume53
Issue number3
Publication statusPublished - Mar 1998

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Kidney-pancreas transplantation: 23 consecutive cases.'. Together they form a unique fingerprint.

Cite this