Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients

Andrea Salonia, Francesca D'Addio, Chiara Gremizzi, Alberto Briganti, Federico Dehò, Rossana Caldara, Elena Orsenigo, Carlo Staudacher, Carlo Socci, Patrizio Rigatti, Antonio Secchi, Francesco Montorsi, Paolo Fiorina

Research output: Contribution to journalArticle

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Abstract

Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalTransplantation
Volume92
Issue number7
DOIs
Publication statusPublished - Oct 15 2011

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Pancreas Transplantation
Kidney Transplantation
Type 1 Diabetes Mellitus
Chronic Kidney Failure
Kidney
Pancreas
Hemodynamics
Sensory Thresholds
Androgens
Physical Examination
Healthy Volunteers
Hand
Steroids
Quality of Life
Depression
Equipment and Supplies

Keywords

  • Hormones
  • Kidney transplantation
  • Pancreas transplantation
  • Sexual function
  • Type 1 diabetes

ASJC Scopus subject areas

  • Transplantation

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Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients. / Salonia, Andrea; D'Addio, Francesca; Gremizzi, Chiara; Briganti, Alberto; Dehò, Federico; Caldara, Rossana; Orsenigo, Elena; Staudacher, Carlo; Socci, Carlo; Rigatti, Patrizio; Secchi, Antonio; Montorsi, Francesco; Fiorina, Paolo.

In: Transplantation, Vol. 92, No. 7, 15.10.2011, p. 803-808.

Research output: Contribution to journalArticle

Salonia, Andrea ; D'Addio, Francesca ; Gremizzi, Chiara ; Briganti, Alberto ; Dehò, Federico ; Caldara, Rossana ; Orsenigo, Elena ; Staudacher, Carlo ; Socci, Carlo ; Rigatti, Patrizio ; Secchi, Antonio ; Montorsi, Francesco ; Fiorina, Paolo. / Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients. In: Transplantation. 2011 ; Vol. 92, No. 7. pp. 803-808.
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T1 - Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients

AU - Salonia, Andrea

AU - D'Addio, Francesca

AU - Gremizzi, Chiara

AU - Briganti, Alberto

AU - Dehò, Federico

AU - Caldara, Rossana

AU - Orsenigo, Elena

AU - Staudacher, Carlo

AU - Socci, Carlo

AU - Rigatti, Patrizio

AU - Secchi, Antonio

AU - Montorsi, Francesco

AU - Fiorina, Paolo

PY - 2011/10/15

Y1 - 2011/10/15

N2 - Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.

AB - Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.

KW - Hormones

KW - Kidney transplantation

KW - Pancreas transplantation

KW - Sexual function

KW - Type 1 diabetes

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