Abstract
Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 803-808 |
| Number of pages | 6 |
| Journal | Transplantation |
| Volume | 92 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 15 2011 |
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Keywords
- Hormones
- Kidney transplantation
- Pancreas transplantation
- Sexual function
- Type 1 diabetes
ASJC Scopus subject areas
- Transplantation
Cite this
Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients. / Salonia, Andrea; D'Addio, Francesca; Gremizzi, Chiara; Briganti, Alberto; Dehò, Federico; Caldara, Rossana; Orsenigo, Elena; Staudacher, Carlo; Socci, Carlo; Rigatti, Patrizio; Secchi, Antonio; Montorsi, Francesco; Fiorina, Paolo.
In: Transplantation, Vol. 92, No. 7, 15.10.2011, p. 803-808.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients
AU - Salonia, Andrea
AU - D'Addio, Francesca
AU - Gremizzi, Chiara
AU - Briganti, Alberto
AU - Dehò, Federico
AU - Caldara, Rossana
AU - Orsenigo, Elena
AU - Staudacher, Carlo
AU - Socci, Carlo
AU - Rigatti, Patrizio
AU - Secchi, Antonio
AU - Montorsi, Francesco
AU - Fiorina, Paolo
PY - 2011/10/15
Y1 - 2011/10/15
N2 - Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.
AB - Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.
KW - Hormones
KW - Kidney transplantation
KW - Pancreas transplantation
KW - Sexual function
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=80053313338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053313338&partnerID=8YFLogxK
U2 - 10.1097/TP.0b013e31822c6eb8
DO - 10.1097/TP.0b013e31822c6eb8
M3 - Article
C2 - 21822170
AN - SCOPUS:80053313338
VL - 92
SP - 803
EP - 808
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 7
ER -