Kidney-sparing radiotherapy by multiple-field three-dimensional technique in the postoperative management of patients with gastric cancer: Comparison with standard two-field conformal technique

Michela Marcenaro, Franca Foppiano, Silvia Durzu, Salvina Barra, Renzo Corvò

Research output: Contribution to journalArticle

Abstract

Aims and background: The opposed two-field technique is the standard approach for delivering adjuvant radiotherapy to patients with resected gastric cancer. Since a considerable radiation dose may reach both kidneys with this beam arrangement, with a potential risk of late effects, we investigated whether the CT-based multiple-field (M-F) approach was superior in terms of sparing critical organs at risk. Methods: From March 2001 to March 2004, 19 patients with radically resected gastric cancer entered the study. They were treated with adjuvant chemoradiotherapy according to the INT 0116 protocol. For each patient dose-volume histograms were calculated and the volume values of both kidneys and liver receiving 25 Gy (V25), 30 Gy (V30) and 40 Gy (V40) individually estimated with the M-F and two-field techniques were compared in detail. Results: Right kidney median V 25, V 30 and V 40 values for the two-field and M-F techniques were 1.50%, 0%, 0% and 0%, 0% and 0%, respectively (P 25, V 30 and V 40 values for the M-F and two-field technique were 16%, 9.80%, 0.90% and 33.20%, 30.20%, 21.40% (P 25, V 30 and V 40 values for the M-F and two-field techniques were 51.30%, 22.30%, 8.90% and 13.30%, 11.60%, 8.10%, respectively (P

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalTumori
Volume92
Issue number1
Publication statusPublished - Jan 2006

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Stomach Neoplasms
Radiotherapy
Kidney
Adjuvant Chemoradiotherapy
Organs at Risk
Adjuvant Radiotherapy
Radiation
Liver
iodonitrotetrazolium

Keywords

  • Gastric cancer
  • Radiotherapy
  • Technique investigation

ASJC Scopus subject areas

  • Cancer Research

Cite this

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title = "Kidney-sparing radiotherapy by multiple-field three-dimensional technique in the postoperative management of patients with gastric cancer: Comparison with standard two-field conformal technique",
abstract = "Aims and background: The opposed two-field technique is the standard approach for delivering adjuvant radiotherapy to patients with resected gastric cancer. Since a considerable radiation dose may reach both kidneys with this beam arrangement, with a potential risk of late effects, we investigated whether the CT-based multiple-field (M-F) approach was superior in terms of sparing critical organs at risk. Methods: From March 2001 to March 2004, 19 patients with radically resected gastric cancer entered the study. They were treated with adjuvant chemoradiotherapy according to the INT 0116 protocol. For each patient dose-volume histograms were calculated and the volume values of both kidneys and liver receiving 25 Gy (V25), 30 Gy (V30) and 40 Gy (V40) individually estimated with the M-F and two-field techniques were compared in detail. Results: Right kidney median V 25, V 30 and V 40 values for the two-field and M-F techniques were 1.50{\%}, 0{\%}, 0{\%} and 0{\%}, 0{\%} and 0{\%}, respectively (P 25, V 30 and V 40 values for the M-F and two-field technique were 16{\%}, 9.80{\%}, 0.90{\%} and 33.20{\%}, 30.20{\%}, 21.40{\%} (P 25, V 30 and V 40 values for the M-F and two-field techniques were 51.30{\%}, 22.30{\%}, 8.90{\%} and 13.30{\%}, 11.60{\%}, 8.10{\%}, respectively (P",
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T1 - Kidney-sparing radiotherapy by multiple-field three-dimensional technique in the postoperative management of patients with gastric cancer

T2 - Comparison with standard two-field conformal technique

AU - Marcenaro, Michela

AU - Foppiano, Franca

AU - Durzu, Silvia

AU - Barra, Salvina

AU - Corvò, Renzo

PY - 2006/1

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N2 - Aims and background: The opposed two-field technique is the standard approach for delivering adjuvant radiotherapy to patients with resected gastric cancer. Since a considerable radiation dose may reach both kidneys with this beam arrangement, with a potential risk of late effects, we investigated whether the CT-based multiple-field (M-F) approach was superior in terms of sparing critical organs at risk. Methods: From March 2001 to March 2004, 19 patients with radically resected gastric cancer entered the study. They were treated with adjuvant chemoradiotherapy according to the INT 0116 protocol. For each patient dose-volume histograms were calculated and the volume values of both kidneys and liver receiving 25 Gy (V25), 30 Gy (V30) and 40 Gy (V40) individually estimated with the M-F and two-field techniques were compared in detail. Results: Right kidney median V 25, V 30 and V 40 values for the two-field and M-F techniques were 1.50%, 0%, 0% and 0%, 0% and 0%, respectively (P 25, V 30 and V 40 values for the M-F and two-field technique were 16%, 9.80%, 0.90% and 33.20%, 30.20%, 21.40% (P 25, V 30 and V 40 values for the M-F and two-field techniques were 51.30%, 22.30%, 8.90% and 13.30%, 11.60%, 8.10%, respectively (P

AB - Aims and background: The opposed two-field technique is the standard approach for delivering adjuvant radiotherapy to patients with resected gastric cancer. Since a considerable radiation dose may reach both kidneys with this beam arrangement, with a potential risk of late effects, we investigated whether the CT-based multiple-field (M-F) approach was superior in terms of sparing critical organs at risk. Methods: From March 2001 to March 2004, 19 patients with radically resected gastric cancer entered the study. They were treated with adjuvant chemoradiotherapy according to the INT 0116 protocol. For each patient dose-volume histograms were calculated and the volume values of both kidneys and liver receiving 25 Gy (V25), 30 Gy (V30) and 40 Gy (V40) individually estimated with the M-F and two-field techniques were compared in detail. Results: Right kidney median V 25, V 30 and V 40 values for the two-field and M-F techniques were 1.50%, 0%, 0% and 0%, 0% and 0%, respectively (P 25, V 30 and V 40 values for the M-F and two-field technique were 16%, 9.80%, 0.90% and 33.20%, 30.20%, 21.40% (P 25, V 30 and V 40 values for the M-F and two-field techniques were 51.30%, 22.30%, 8.90% and 13.30%, 11.60%, 8.10%, respectively (P

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