Kidney Transplant: Usefulness of Real-Time Elastography (RTE) in the Diagnosis of Graft Interstitial Fibrosis

Antonio Orlacchio, Fabrizio Chegai, Costantino Del Giudice, Alessandro Anselmo, Giuseppe Iaria, Giampiero Palmieri, Elena Di Caprera, Daniela Tosti, Elisa Costanzo, Giuseppe Tisone, Giovanni Simonetti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study is to evaluate the usefulness of real-time elastography (RTE) in the diagnosis of graft interstitial fibrosis. We prospectively enrolled 50 patients clinically suspected of graft fibrosis. RTE was performed with a broadband linear transducer using a dedicated ultrasound machine. Tissue mean elasticity (TME) was calculated by two blinded operators. All patients underwent biopsy after RTE. To determine cortical fibrosis Banff score was used. The receiver operating characteristic curves analysis was performed to evaluate the accuracy of TME to discriminate between patients with mild fibrosis (F1) versus patients with moderate to severe fibrosis (F2-F3). Inverse correlation between TME values and the degree of fibrosis has been shown (. p

Original languageEnglish
Pages (from-to)2564-2572
Number of pages9
JournalUltrasound in Medicine and Biology
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Allograft biopsy
  • Elasticity imaging
  • Graft histology
  • Kidney transplantation
  • Ultrasound imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics
  • Medicine(all)

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