Kidney transplantation, bioengineering and regeneration: An originally immunology-based discipline destined to transition towards ad hoc organ manufacturing and repair

Jeffrey Rogers, Ravi Katari, Sheyna Gifford, Riccardo Tamburrini, Lauren Edgar, Marcia R. Voigt, Sean V. Murphy, Daniel Igel, Sara Mancone, Tyler Callese, Nicola Colucci, Majid Mirzazadeh, Andrea Peloso, Joao Paulo Zambon, Alan C. Farney, Robert J. Stratta, Giuseppe Orlando

Research output: Contribution to journalArticlepeer-review

Abstract

Kidney transplantation (KT), as a modality of renal replacement therapy (RRT), has been shown to be both economically and functionally superior to dialysis for the treatment of end-stage renal disease (ESRD). Progress in KT is limited by two major barriers: a) a chronic and burgeoning shortage of transplantable organs and b) the need for chronic immunosuppression following transplantation. Although ground-breaking advances in transplant immunology have improved patient survival and graft durability, a new pathway of innovation is needed in order to overcome current obstacles. Regenerative medicine (RM) holds the potential to shift the paradigm in RRT, through organ bioengineering. Manufactured organs represent a potentially inexhaustible source of transplantable grafts that would bypass the need for immunosuppressive drugs by using autologous cells to repopulate extracellular matrix (ECM) scaffolds. This overview discusses the current status of renal transplantation while reviewing the most promising innovations in RM therapy as applied to RRT.

Original languageEnglish
Pages (from-to)169-182
Number of pages14
JournalExpert Review of Clinical Immunology
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Bioengineering
  • Decellularization
  • Extracellular matrix
  • Kidney transplantation
  • Regenerative medicine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Kidney transplantation, bioengineering and regeneration: An originally immunology-based discipline destined to transition towards ad hoc organ manufacturing and repair'. Together they form a unique fingerprint.

Cite this