Kidney Transplantation Combined With Other Organs in Bologna: An Update

R. Bertelli, B. Nardo, G. Cavallari, G. Ercolani, A. Lauro, F. Neri, M. Tsivian, G. L. Grazi, P. M. Mikus, E. Pilato, E. Mikus, G. Arpesella, A. D. Pinna, S. Stefoni, G. Fuga, A. Faenza

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Abstract

Background: We retrospectively reviewed our experience in combined liver-kidney (L-KT) and heart-kidney (H-KT) transplantations. Patients and Methods: Between January 1997 and April 2007, we performed 25 L-KT and 5 H-KT. Patient mean age was 51 ± 8 years in L-KT and 43 ± 11 years in H-KT. The main cause of liver failure was chronic viral hepatitis (14 cases). Etiology of heart failure was dilated cardiomyopathy and hypertrophic cardiomyopathy (4 and 1 patients, respectively). The main causes of renal failure in L-KT were chronic glomerulonephritis (n = 8) and polycystic disease (n = 7). Etiology of renal failure in H-KT was interstitial nephropathy (n = 2), vascular nephropathy (n = 2), and chronic glomerulonephritis (n = 1). Results: Mean follow-up was 32 ± 26 months in L-KT and 24 ± 17 months in H-KT. Immunosuppression was cyclosporine-based (n = 4) or tacrolimus-based (n = 21) in L-KT and cyclosporine-based in H-KT. Acute rejection rate was 8% for both liver and kidney in L-KT; 80% (mild) for heart and 40% for kidney in H-KT. In the L-KT group, there was no primary graft nonfunction (PGNF). Two patients experienced liver delayed graft function (DGF); 1 patient required postoperative dialysis. One-year graft and patient survivals were both 84% and overall graft and patient survival was 76%. In the H-KT group, 3 patients needed postoperative dialysis and 1 required a cardiac assistance device for 48 hours; overall graft and patient survival was 100% with good cardiac and renal functions. Conclusion: Our experience confirmed that H-KT and L-KT are safe procedures, offering good long-term results.

Original languageEnglish
Pages (from-to)1867-1868
Number of pages2
JournalTransplantation Proceedings
Volume40
Issue number6
DOIs
Publication statusPublished - Jul 2008

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Bertelli, R., Nardo, B., Cavallari, G., Ercolani, G., Lauro, A., Neri, F., Tsivian, M., Grazi, G. L., Mikus, P. M., Pilato, E., Mikus, E., Arpesella, G., Pinna, A. D., Stefoni, S., Fuga, G., & Faenza, A. (2008). Kidney Transplantation Combined With Other Organs in Bologna: An Update. Transplantation Proceedings, 40(6), 1867-1868. https://doi.org/10.1016/j.transproceed.2008.05.024