KIF21A mRNA expression in patients with Down syndrome

Michele Salemi, Concetta Barone, Carmelo Romano, Federico Ridolfo, Cataldo Scavuzzo, Rita Anna Cantarella, Maria Grazia Salluzzo, Aldo E. Calogero, Corrado Romano, Paolo Bosco

Research output: Contribution to journalArticlepeer-review

Abstract

Down syndrome (DS) is a chromosomal disorder caused by chromosome 21 trisomy and is the most frequent genetic cause of intellectual disability. The gene for the kinesin family member 21A (KIF21A), is a member of the kinesin superfamily involved in the anterograde fast axonal transport. In this study, we have evaluated the possible differential expression of KIF21A mRNA, by qRT-PCR, in peripheral blood leukocytes of DS subjects and it compared with the normal population. In the assumption that changes in KIF21A gene expression levels may affect the axonal transport and the development of the nervous system of subjects with DS. In the present case-control study, KIF21A gene expression was increased in 72.72 % of DS samples compared with normal subjects. This finding suggests that changes in the expression levels of KIF21A in DS subjects may affect the axonal transport and the development of the nervous system.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
JournalNeurological Sciences
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Down syndrome
  • KIF21A gene
  • Kinesin family
  • mRNA expression
  • qRT-PCR

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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