Abstract
Kinesins are microtubule-dependent molecular motors involved in intracellular transport and mitosis. Here, we report the cloning, sequencing, mapping, and expression of a novel member of the kinesin superfamily. The sequence of this newly identified human cDNA reveals an open reading frame encoding a putative protein of 792 residues. Based on its high sequence similarity to the kinesin-like molecule KIF3B, we named this protein KIF3C. KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain. Fluorescence in situ hybridization reveals that, in the human genome, the KIF3C gene maps to chromosome 2 at 2p23. The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding. Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells.
| Original language | English |
|---|---|
| Pages (from-to) | 405-408 |
| Number of pages | 4 |
| Journal | Genomics |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 1 1998 |
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- Genetics
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KIF3C, a novel member of the kinesin superfamily : Sequence, expression, and mapping to human chromosome 2 at 2p23. / Sardella, Milena; Navone, Francesca; Rocchi, Mariano; Rubartelli, Anna; Viggiano, Luigi; Vignali, Giovanna; Consalez, G. Giacomo; Sitia, Roberto; Cabibbo, Andrea.
In: Genomics, Vol. 47, No. 3, 01.02.1998, p. 405-408.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - KIF3C, a novel member of the kinesin superfamily
T2 - Sequence, expression, and mapping to human chromosome 2 at 2p23
AU - Sardella, Milena
AU - Navone, Francesca
AU - Rocchi, Mariano
AU - Rubartelli, Anna
AU - Viggiano, Luigi
AU - Vignali, Giovanna
AU - Consalez, G. Giacomo
AU - Sitia, Roberto
AU - Cabibbo, Andrea
PY - 1998/2/1
Y1 - 1998/2/1
N2 - Kinesins are microtubule-dependent molecular motors involved in intracellular transport and mitosis. Here, we report the cloning, sequencing, mapping, and expression of a novel member of the kinesin superfamily. The sequence of this newly identified human cDNA reveals an open reading frame encoding a putative protein of 792 residues. Based on its high sequence similarity to the kinesin-like molecule KIF3B, we named this protein KIF3C. KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain. Fluorescence in situ hybridization reveals that, in the human genome, the KIF3C gene maps to chromosome 2 at 2p23. The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding. Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells.
AB - Kinesins are microtubule-dependent molecular motors involved in intracellular transport and mitosis. Here, we report the cloning, sequencing, mapping, and expression of a novel member of the kinesin superfamily. The sequence of this newly identified human cDNA reveals an open reading frame encoding a putative protein of 792 residues. Based on its high sequence similarity to the kinesin-like molecule KIF3B, we named this protein KIF3C. KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain. Fluorescence in situ hybridization reveals that, in the human genome, the KIF3C gene maps to chromosome 2 at 2p23. The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding. Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells.
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U2 - 10.1006/geno.1997.5123
DO - 10.1006/geno.1997.5123
M3 - Article
VL - 47
SP - 405
EP - 408
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -