Killer anti-idiotypes in the control of fungal infections

W. Magliani, S. Conti, S. Arseni, R. Frazzi, A. Salati, L. Polonelli

Research output: Contribution to journalArticle

Abstract

Killer anti-idiotypes (KTantiId) bear the internal image of Pichia anomala toxin (KT), characterized by microbicidal activity against prokaryotic and eukaryotic pathogenic microorganisms presenting specific cell wall receptors (KTR). KTantiId produced by idiotypic vaccination with a KT-neutralizing monoclonal antibody confer active and passive immunoprotection in experimental models of systemic and vaginal candidiasis. KTantiId-like human natural anti-KTR antibodies are produced in natural infections caused by KT-sensitive microorganisms. KTantiId in the monoclonal and recombinant forms show therapeutic activity in experimental vaginal candidiasis and Pneumocystis carinii pneumonia. Human commensal bacteria expressing KTantiId or killer mimotopes synthesized from the sequence of KtantiId, may represent effective tools to combat fungal infections.

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalCurrent Opinion in Investigational Drugs
Volume2
Issue number4
Publication statusPublished - 2001

Keywords

  • Anti-idiotypes
  • Candidiasis
  • Killer yeast

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Magliani, W., Conti, S., Arseni, S., Frazzi, R., Salati, A., & Polonelli, L. (2001). Killer anti-idiotypes in the control of fungal infections. Current Opinion in Investigational Drugs, 2(4), 477-479.