Killer Cell Immunoglobulin-Like Receptor–Ligand Mismatch in Donor versus Recipient Direction Provides Better Graft-versus-Tumor Effect in Patients with Hematologic Malignancies Undergoing Allogeneic T Cell–Replete Haploidentical Transplantation Followed by Post-Transplant Cyclophosphamide

Stephania Bramanti, Anne Wanquet, Samia Harbi, Sabine Fürst, Faezeh Legrand, Catherine Faucher, Angela Granata, Boris Calmels, Claude Lemarie, Christophe Picard, Christian Chabannon, Pierre Jean Weiller, Luca Castagna, Didier Blaise, Raynier Devillier

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the impact of unidirectional donor versus recipient killer cell immunoglobulin-like receptor (KIR)–ligand mismatch (KIR-Lmm) on the outcomes of T cell–replete haploidentical stem cell transplantation (Haplo-SCT) with post-transplant cyclophosphamide (PT-Cy) in a cohort of 144 patients treated for various hematologi diseases. We separately analyzed 81 patients in complete remission (CR group) and 63 with active disease (no CR group) at the time of Haplo-SCT. One-third of patients in each group had KIR-Lmm. In the no CR group, KIR-Lmm was associated with a significantly lower incidence of relapse (hazard ratio,.21; P =.013) and better progression-free survival (hazard ratio,.42; P =.028), with no significant increase in graft-versus-host disease incidence or nonrelapse mortality. In contrast, in the CR group no benefit of KIR-Lmm was observed. Our results encourage considering KIR-Lmm as an additional tool to improve donor selection for T cell–replete Haplo-SCT with PT-Cy, especially in patients with high-risk diseases.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

Keywords

  • Graft-versus-leukemia effect
  • Killer cell immunoglobulin-like receptor
  • Natural killer cells
  • T cell–replete haploidentical stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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