Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome

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3 Citations (Scopus)

Abstract

Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8+ T, γδ T and CD4+ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Mar 31 2016

Fingerprint

Down Syndrome
Gene Expression
Leukocytes
Fibroblasts
Epstein-Barr Virus Infections
Virus Diseases
Intellectual Disability
Reverse Transcription
Blood Proteins
Viruses
T-Lymphocytes
Polymerase Chain Reaction
Messenger RNA
Genes

Keywords

  • Down syndrome
  • Ksp37 gene
  • mRNA expression
  • qRT-PCR

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

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title = "Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome",
abstract = "Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8+ T, γδ T and CD4+ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.",
keywords = "Down syndrome, Ksp37 gene, mRNA expression, qRT-PCR",
author = "Michele Salemi and Concetta Barone and Morale, {Maria Concetta} and Salvatore Caniglia and Salluzzo, {Maria Grazia} and Rando, {Rosanna G Galati} and Alda Ragalmuto and Paolo Bosco and Corrado Romano",
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AU - Salemi, Michele

AU - Barone, Concetta

AU - Morale, Maria Concetta

AU - Caniglia, Salvatore

AU - Salluzzo, Maria Grazia

AU - Rando, Rosanna G Galati

AU - Ragalmuto, Alda

AU - Bosco, Paolo

AU - Romano, Corrado

PY - 2016/3/31

Y1 - 2016/3/31

N2 - Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8+ T, γδ T and CD4+ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.

AB - Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8+ T, γδ T and CD4+ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.

KW - Down syndrome

KW - Ksp37 gene

KW - mRNA expression

KW - qRT-PCR

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