Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients

Bryan J. Traynor, Michael Nalls, Shiao Lin Lai, Raphael J. Gibbs, Jennifer C. Schymick, Sampath Arepalli, Dena Hernandez, Marcel P. Van Der Brug, Janel O. Johnson, Allissa Dillman, Mark Cookson, Cristina Moglia, Andrea Calvo, Gabriella Restagno, Gabriele Mora, Adriano Chiò

Research output: Contribution to journalArticle

Abstract

It was recently reported that rs1541160 on chromosome 1q24.2 has a marked effect on survival of amyotrophic lateral sclerosis (ALS) patients by influencing KIFAP3 expression. The cohorts used in that study were collected from ALS specialty clinics. We attempted to replicate these findings in a population-based cohort of 504 Italian ALS patients. None of 140 SNPs genotyped within the KIFAP3 locus (including rs1541160) had an effect on survival (log-rank P value for rs1541160 = 0.47) or on gene expression in that region. These data illustrate the complexities associated with analyzing ALS phenotypes for association.

Original languageEnglish
Pages (from-to)12335-12338
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number27
DOIs
Publication statusPublished - Jul 6 2010

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Keywords

  • Amyotrophic lateral sclerosis
  • Gene expression quantitative trait loci mapping
  • Genome-wide association study
  • Italian
  • Survival analysis

ASJC Scopus subject areas

  • General

Cite this

Traynor, B. J., Nalls, M., Lai, S. L., Gibbs, R. J., Schymick, J. C., Arepalli, S., Hernandez, D., Van Der Brug, M. P., Johnson, J. O., Dillman, A., Cookson, M., Moglia, C., Calvo, A., Restagno, G., Mora, G., & Chiò, A. (2010). Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients. Proceedings of the National Academy of Sciences of the United States of America, 107(27), 12335-12338. https://doi.org/10.1073/pnas.0914079107