Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog

F. Pagani, M. Zecca, A. Giachetti

Research output: Contribution to journalArticle

Abstract

The H2-receptor antagonists mifentidine and cimetidine were compared for their ability to antagonize the activation of H2-receptors in the conscious dog. Dose-response curves to dimaprit in stimulating gastric secretion were displaced to the right in a dose-related fashion by both drugs. Schild and Eadie-Hofstee analysis of these data indicated that mifentidine and cimetidine inhibited in vivo activation of H2-receptors in a manner compatible with competitive surmountable antagonism. Mifentidine displayed a 24fold greater potency than cimetidine as H2 antagonist in the conscious dog.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume336
Issue number3
DOIs
Publication statusPublished - Sep 1987

Fingerprint

Histamine H2 Receptors
Cimetidine
Stomach
Dogs
Dimaprit
Pharmaceutical Preparations
mifentidine

Keywords

  • Cimetidine
  • Dog
  • Gastric acid
  • Mifentidine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog. / Pagani, F.; Zecca, M.; Giachetti, A.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 336, No. 3, 09.1987, p. 349-351.

Research output: Contribution to journalArticle

@article{3253a3dd472f453885b1349bb6bbd388,
title = "Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog",
abstract = "The H2-receptor antagonists mifentidine and cimetidine were compared for their ability to antagonize the activation of H2-receptors in the conscious dog. Dose-response curves to dimaprit in stimulating gastric secretion were displaced to the right in a dose-related fashion by both drugs. Schild and Eadie-Hofstee analysis of these data indicated that mifentidine and cimetidine inhibited in vivo activation of H2-receptors in a manner compatible with competitive surmountable antagonism. Mifentidine displayed a 24fold greater potency than cimetidine as H2 antagonist in the conscious dog.",
keywords = "Cimetidine, Dog, Gastric acid, Mifentidine",
author = "F. Pagani and M. Zecca and A. Giachetti",
year = "1987",
month = "9",
doi = "10.1007/BF00172689",
language = "English",
volume = "336",
pages = "349--351",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog

AU - Pagani, F.

AU - Zecca, M.

AU - Giachetti, A.

PY - 1987/9

Y1 - 1987/9

N2 - The H2-receptor antagonists mifentidine and cimetidine were compared for their ability to antagonize the activation of H2-receptors in the conscious dog. Dose-response curves to dimaprit in stimulating gastric secretion were displaced to the right in a dose-related fashion by both drugs. Schild and Eadie-Hofstee analysis of these data indicated that mifentidine and cimetidine inhibited in vivo activation of H2-receptors in a manner compatible with competitive surmountable antagonism. Mifentidine displayed a 24fold greater potency than cimetidine as H2 antagonist in the conscious dog.

AB - The H2-receptor antagonists mifentidine and cimetidine were compared for their ability to antagonize the activation of H2-receptors in the conscious dog. Dose-response curves to dimaprit in stimulating gastric secretion were displaced to the right in a dose-related fashion by both drugs. Schild and Eadie-Hofstee analysis of these data indicated that mifentidine and cimetidine inhibited in vivo activation of H2-receptors in a manner compatible with competitive surmountable antagonism. Mifentidine displayed a 24fold greater potency than cimetidine as H2 antagonist in the conscious dog.

KW - Cimetidine

KW - Dog

KW - Gastric acid

KW - Mifentidine

UR - http://www.scopus.com/inward/record.url?scp=0023229664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023229664&partnerID=8YFLogxK

U2 - 10.1007/BF00172689

DO - 10.1007/BF00172689

M3 - Article

C2 - 2891046

AN - SCOPUS:0023229664

VL - 336

SP - 349

EP - 351

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 3

ER -