Kinetic analysis of the interaction of mifentidine with gastric H2-receptors in the conscious dog

F. Pagani, M. Zecca, A. Giachetti

Research output: Contribution to journalArticlepeer-review

Abstract

The H2-receptor antagonists mifentidine and cimetidine were compared for their ability to antagonize the activation of H2-receptors in the conscious dog. Dose-response curves to dimaprit in stimulating gastric secretion were displaced to the right in a dose-related fashion by both drugs. Schild and Eadie-Hofstee analysis of these data indicated that mifentidine and cimetidine inhibited in vivo activation of H2-receptors in a manner compatible with competitive surmountable antagonism. Mifentidine displayed a 24fold greater potency than cimetidine as H2 antagonist in the conscious dog.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume336
Issue number3
DOIs
Publication statusPublished - Sep 1987

Keywords

  • Cimetidine
  • Dog
  • Gastric acid
  • Mifentidine

ASJC Scopus subject areas

  • Pharmacology

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