Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens

Lorenzo Drago, E. De Vecchi, L. Nicola, D. Legnani, M. R. Gismondo

Research output: Contribution to journalArticlepeer-review


The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, β-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to β-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from ≤0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides.

Original languageEnglish
Pages (from-to)655-663
Number of pages9
Issue number10
Publication statusPublished - Oct 2005


  • Haemophilus influenzae
  • Macrolides
  • Moraxella catarrhalis
  • Streptococci
  • Telithromycin

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Pathology and Forensic Medicine


Dive into the research topics of 'Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens'. Together they form a unique fingerprint.

Cite this