Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens

Lorenzo Drago, E. De Vecchi, L. Nicola, D. Legnani, M. R. Gismondo

Research output: Contribution to journalArticlepeer-review

Abstract

The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, β-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to β-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from ≤0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides.

Original languageEnglish
Pages (from-to)655-663
Number of pages9
JournalAPMIS
Volume113
Issue number10
Publication statusPublished - Oct 2005

Keywords

  • Haemophilus influenzae
  • Macrolides
  • Moraxella catarrhalis
  • Streptococci
  • Telithromycin

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Pathology and Forensic Medicine

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