Kinetics of circulating plasma cell-free DNA in paediatric classical Hodgkin lymphoma

Simona Primerano, Roberta Burnelli, Elisa Carraro, Marta Pillon, Caterina Elia, Piero Farruggia, Alessandra Sala, Luciana Vinti, Salvatore Buffardi, Giuseppe Basso, Maurizio Mascarin, Lara Mussolin

Research output: Contribution to journalArticlepeer-review

Abstract

Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA at diagnosis was correlated with presence of B symptoms (p=0.027) and high erythrocyte sedimentation rate (p=0.049). We found that the increasing of plasma cfDNA after first chemotherapy cycle seems to be associated with a worse prognosis (p=0.049). Levels of plasma cfDNA might constitute an interesting non-invasive tool in cHL patients' management.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalJournal of Cancer
Volume7
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Cell-free DNA
  • Childhood
  • Classical Hodgkin Lymphoma

ASJC Scopus subject areas

  • Oncology

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