Kinetics of distribution of amphetamine in cats

Roberto Latini; Gian Franco Placidi; Emma Riva; Pantaleo Fornaro; Maurizio Guarneri; Paolo Lucio Morselli

doi:10.1007/BF00426782

Kinetics of distribution of amphetamine in cats

Roberto Latini, Gian Franco Placidi, Emma Riva, Pantaleo Fornaro, Maurizio Guarneri, Paolo Lucio Morselli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

Original language	English
Pages (from-to)	209-215
Number of pages	7
Journal	Psychopharmacology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1007/BF00426782
Publication status	Published - Jan 1977

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Keywords

Amphetamine
Cat
Distribution
Para-hydroxy-amphetamine

ASJC Scopus subject areas

Pharmacology

Cite this

Latini, R., Placidi, G. F., Riva, E., Fornaro, P., Guarneri, M., & Morselli, P. L. (1977). Kinetics of distribution of amphetamine in cats. Psychopharmacology, 54(2), 209-215. https://doi.org/10.1007/BF00426782

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10.1007/BF00426782