Kinetics of distribution of amphetamine in cats

Roberto Latini, Gian Franco Placidi, Emma Riva, Pantaleo Fornaro, Maurizio Guarneri, Paolo Lucio Morselli

Research output: Contribution to journalArticle

Abstract

The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

Original languageEnglish
Pages (from-to)209-215
Number of pages7
JournalPsychopharmacology
Volume54
Issue number2
DOIs
Publication statusPublished - Jan 1977

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Keywords

  • Amphetamine
  • Cat
  • Distribution
  • Para-hydroxy-amphetamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Latini, R., Placidi, G. F., Riva, E., Fornaro, P., Guarneri, M., & Morselli, P. L. (1977). Kinetics of distribution of amphetamine in cats. Psychopharmacology, 54(2), 209-215. https://doi.org/10.1007/BF00426782