Kinetics of distribution of amphetamine in cats

Roberto Latini; Gian Franco Placidi; Emma Riva; Pantaleo Fornaro; Maurizio Guarneri; Paolo Lucio Morselli

doi:10.1007/BF00426782

Kinetics of distribution of amphetamine in cats

Roberto Latini, Gian Franco Placidi, Emma Riva, Pantaleo Fornaro, Maurizio Guarneri, Paolo Lucio Morselli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

Original language	English
Pages (from-to)	209-215
Number of pages	7
Journal	Psychopharmacology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1007/BF00426782
Publication status	Published - Jan 1977

Keywords

Amphetamine
Cat
Distribution
Para-hydroxy-amphetamine

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF00426782

Cite this

@article{122bdaa4e28a4e6295efd96b1388b06d,

title = "Kinetics of distribution of amphetamine in cats",

abstract = "The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.",

keywords = "Amphetamine, Cat, Distribution, Para-hydroxy-amphetamine",

author = "Roberto Latini and Placidi, {Gian Franco} and Emma Riva and Pantaleo Fornaro and Maurizio Guarneri and Morselli, {Paolo Lucio}",

year = "1977",

month = jan,

doi = "10.1007/BF00426782",

language = "English",

volume = "54",

pages = "209--215",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Kinetics of distribution of amphetamine in cats

AU - Latini, Roberto

AU - Placidi, Gian Franco

AU - Riva, Emma

AU - Fornaro, Pantaleo

AU - Guarneri, Maurizio

AU - Morselli, Paolo Lucio

PY - 1977/1

Y1 - 1977/1

N2 - The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

AB - The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxyamphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

KW - Amphetamine

KW - Cat

KW - Distribution

KW - Para-hydroxy-amphetamine

UR - http://www.scopus.com/inward/record.url?scp=0017729505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017729505&partnerID=8YFLogxK

U2 - 10.1007/BF00426782

DO - 10.1007/BF00426782

M3 - Article

C2 - 412217

AN - SCOPUS:0017729505

VL - 54

SP - 209

EP - 215

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -

Kinetics of distribution of amphetamine in cats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this