Kinetics of effector functions and phenotype of virus-specific and γδ T lymphocytes in primary human cytomegalovirus infection during pregnancy

Chiara Fornara, Daniele Lilleri, M. Grazia Revello, Milena Furione, Maurizio Zavattoni, Elisa Lenta, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review

Abstract

The T-cell response to human cytomegalovirus (HCMV) primary infection was analyzed in 27 pregnant women during the first year after primary HCMV infection. Pregnant women with remote HCMV infection were enrolled as controls. Interferon-γ-producing T cells were readily detected at levels comparable (CD4 +) or higher (CD8 +) than controls, whereas the CD4 + and CD8 + lymphoproliferative response as well as IL-2 production was significantly reduced with respect to controls for at least 9 months after infection. In addition, CD45RA reexpression as well as cytotoxic T lymphocyte activity and perforin expression were the major components of the adaptive CD4 + and CD8 + T-cell immune response, while Vδ2 - γδ T-cell expansion in response to HCMV infection followed kinetics similar to that of CD8 + T cells. Reduced CD45RA re-expression directly correlated with HCMV transmission to the fetus, thus providing an important prognostic parameter.

Original languageEnglish
Pages (from-to)1054-1064
Number of pages11
JournalJournal of Clinical Immunology
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2011

Keywords

  • γδ T cells
  • Cytotoxicity
  • Perforin
  • Primary HCMV infection
  • T-cell immune response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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