Kinetics of erythroid and myeloid stem cells in post-hypoxia polycythaemia

C. Peschle, M. C. Magli, C. Cillo, F. Lettieri, A. Genovese, F. Pizzella, A. Soricelli

Research output: Contribution to journalArticle

Abstract

The number of erythroid burst- (BFU-E) and colony-forming units (CFU-E), as well as of myeloid-macrophage colony-forming units (DFU-C), has been evaluated in tibial marrow and spleen of ex-hypoxic polycythaemic mice, at sequential time intervals after the end of hypoxia. In both marrow and spleen, the kinetics of the CFU-E pool is characterized by a sharp fall from above normal to lower than normal values. BFU-E and CFU-C however rise from below normal to higher levels. These results have been correlated with both the erythropoietin (Ep) and the erythropoietic activity curves. It is apparent that Ep levels largely control both the differentiation and the amplification of the CFU-E pool and it is suggested that Ep may act as a 'survival factor' at the CFU-E level and/or increase the flow of cells from BFU-E to CFU-E. The difference in response between CFU-E and BFU-E favours a clearcut distinction between these populations, whereas the similarity between the BFU-E and CFU-E response suggests a close relationship between these two cell populations. It is also of interest that the murine spleen functions as a large reservoir of erythroid microenvironment for hypoxia-induced stress erythropoiesis.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalBritish Journal of Haematology
Volume37
Issue number3
Publication statusPublished - 1977

    Fingerprint

ASJC Scopus subject areas

  • Hematology

Cite this

Peschle, C., Magli, M. C., Cillo, C., Lettieri, F., Genovese, A., Pizzella, F., & Soricelli, A. (1977). Kinetics of erythroid and myeloid stem cells in post-hypoxia polycythaemia. British Journal of Haematology, 37(3), 345-352.