Kinetics of fenfluramine isomers in the rat

S. Caccia, G. Dagnino, S. Garattini, G. Guiso, R. Madonna, M. G. Zanini

Research output: Contribution to journalArticlepeer-review

Abstract

The kinetics of fenfluramine isomers were studied in the rat following oral doses of racemic fenfluramine. The data, analyzed using an analogue computer, indicate that the d-fenfluramine is metabolised and excreted at a slower rate than the 1-isomer, resulting in higher plasma and brain concentrations. The kinetic parameters of both isomers were dose-dependent. The rates of disappearance decreased as the dose was raised. The increase in brain area under the curves (AUC) was much greater than the increase of the dose. These findings suggested the rat has a limited capacity for disposition of fenfluramine.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume6
Issue number4
DOIs
Publication statusPublished - Oct 1981

Keywords

  • Fenfluramine
  • isomers
  • kinetics
  • rat

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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