Kinetics of furosemide in children with chronic renal failure undergoing regular haemodialysis

E. Riva, E. Fossali, A. Bettinelli

Research output: Contribution to journalArticle

Abstract

Furosemide was measured by gas-liquid chromatography in blood and dialysis fluid from 7 children with chronic renal failure, undergoing regular haemodialysis. It was administered chronically, in two or three daily doses (4.2-9.4 mg/kg). Two children received 1 mg/kg intravenously for determination of the pharmacokinetics. The half-life was longer than in adults and in anephric patients on haemodialysis. Systemic and renal clearance were also much lower. Plasma protein binding in 2 out of 6 cases was reduced as campared to normal adults. The data do not suggest any need to modify the present dosage schedule despite the 4-5 fold increase in the half-life of furosemide. The contribution of haemodialysis to drug clearance was minimal, and accounted for less than 10% of the total clearance.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 1982

Keywords

  • children
  • dosage schedule
  • furosemide
  • haemodialysis
  • pharmacokinetics
  • renal failure

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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