Cinetica dell'iperbilirubinemia associata a indinavir: Studio caso- controllo

Translated title of the contribution: Kinetics of hyperbilirubinemia associated with indinavir: A case- control study

M. Mongiovetti, G. Barasolo, L. Rizzi, D. Zanaboni, G. Mussati, R. Maserati

Research output: Contribution to journalArticle

Abstract

Objectives: a) To evaluate the relationship between hyperbilirubinemia and other parameters such as HIV infection stage, coinfection with hepatotropic viruses and concomitant antiretroviral treatments in subjects treated with indinavir (IDV)-containing HAART; b) To describe hyperbilirubinemia kinetics in the same cohort. Materials and methods: We evaluated retrospectively a cohort of 104 HIV+ individuals treated with a IDV-containing HAART for at least 12 mos. Hyperbilirubinemia was defined as a plasmatic total bilirubin level above 2.00 mg/dL. Results: Out of 104 pts., 37 (35.6%) resulted hyperbilirubinemic; 21/37 (56.7%) belonged to CDC '93 stage A, 16/37 (43.3%) to stages B and C. HCV coinfection was demonstrated in 18/37 (48.6%). Hyperbilirubinemia arose within the first trimester of treatment in 31/37 pts. (83.7%) and peaked within the second trimester in 21/37 (56.7%). Sixteen pts. were being treated with AZT+ 3TC (43.2%), 11 with d4T+ 3TC (29.8%), 8 with d4T+ddI (21.6%) and 2 with AZT+ddI (5.4%). An elevation of aminotransferases was also documented within the first yr. of treatment in 27/37 pts. (73%).

Original languageItalian
Pages (from-to)90-93
Number of pages4
JournalGiornale Italiano di Malattie Infettive
Volume5
Issue number2
Publication statusPublished - 1999

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ASJC Scopus subject areas

  • Microbiology (medical)

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