TY - JOUR
T1 - Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data
AU - Picariello, Claudio
AU - Lazzeri, Chiara
AU - Valente, Serafina
AU - Chiostri, Marco
AU - Attan, Paola
AU - Gensini, Gian Franco
PY - 2010
Y1 - 2010
N2 - Background: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. Aims: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. Results: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 0.90; P 0.051) and non-survivors (R2 0.63; P 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 0.94; P 0.032) while non survivors did not (R2 0.68; P 0.178). Conclusions: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the 'dynamic' approach may be more reliable that the static one especially in cardiogenic shock.
AB - Background: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. Aims: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. Results: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 0.90; P 0.051) and non-survivors (R2 0.63; P 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 0.94; P 0.032) while non survivors did not (R2 0.68; P 0.178). Conclusions: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the 'dynamic' approach may be more reliable that the static one especially in cardiogenic shock.
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U2 - 10.3109/17482941.2010.498920
DO - 10.3109/17482941.2010.498920
M3 - Article
C2 - 20698733
AN - SCOPUS:77956292797
VL - 12
SP - 96
EP - 101
JO - Acute Cardiac Care
JF - Acute Cardiac Care
SN - 1748-2941
IS - 3
ER -