Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data

Claudio Picariello, Chiara Lazzeri, Serafina Valente, Marco Chiostri, Paola Attan, Gian Franco Gensini

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Abstract

Background: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. Aims: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. Results: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 0.90; P 0.051) and non-survivors (R2 0.63; P 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 0.94; P 0.032) while non survivors did not (R2 0.68; P 0.178). Conclusions: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the 'dynamic' approach may be more reliable that the static one especially in cardiogenic shock.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalAcute Cardiac Care
Volume12
Issue number3
DOIs
Publication statusPublished - 2010

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Emergency Medicine
  • Medicine(all)

Cite this

Picariello, C., Lazzeri, C., Valente, S., Chiostri, M., Attan, P., & Gensini, G. F. (2010). Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data. Acute Cardiac Care, 12(3), 96-101. https://doi.org/10.3109/17482941.2010.498920