Kinetics of surfactant in respiratory diseases of the newborn infant

G. Verlato, P. E. Cogo, E. Benetti, S. Gomirato, A. Gucciardi, V. P. Carnielli

Research output: Contribution to journalArticlepeer-review


Deficiency or dysfunction of pulmonary surfactant plays a critical role in the pathogenesis of respiratory diseases in the newborn. We describe the studies made by applying two recently developed methods to measure surfactant kinetics. The first allows the measurement of endogenous surfactant phosphatidylcholine (PC) synthesis and kinetics by a constant intravenous infusion of glucose or fatty acids labeled with stable isotope 13C. The second method consists of endotracheal administration of a tracer dose of 13C- labeled dipalmitoyl-phosphatidylcholine (DPPC) to measure disaturated- phosphatidylcholine (DSPC) half-life and apparent pool size. We present the results of surfactant kinetics in some of the respiratory diseases of the newborn infant.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue numberSUPPL. 2
Publication statusPublished - Nov 2004


  • Kinetics
  • Newborn infant
  • Respiratory diseases
  • Stable isotopes
  • Surfactant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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