TY - JOUR
T1 - Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats
AU - Madeddu, P.
AU - Glorioso, N.
AU - Pinna Parpaglia, P.
AU - Demontis, M. P.
AU - Varoni, M. V.
AU - Fattaccio, M. C.
AU - Sabino, G.
AU - Pisanu, G.
AU - Patteri, G.
AU - Anania, V.
PY - 1992
Y1 - 1992
N2 - Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.
AB - Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.
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M3 - Article
C2 - 1462856
AN - SCOPUS:0026785872
VL - 38
SP - 156
EP - 162
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - SUPPL. III
ER -