Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats

P. Madeddu; N. Glorioso; P. Pinna Parpaglia; M. P. Demontis; M. V. Varoni; M. C. Fattaccio; G. Sabino; G. Pisanu; G. Patteri; V. Anania

Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats

P. Madeddu, N. Glorioso, P. Pinna Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, G. Sabino, G. Pisanu, G. Patteri, V. Anania

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B₂-receptor antagonist D-Arg[Hyp³,Thi⁵,D-Tic⁷,Oic⁸]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.

Original language	English
Pages (from-to)	156-162
Number of pages	7
Journal	Agents and Actions
Volume	38
Issue number	SUPPL. III
Publication status	Published - 1992

ASJC Scopus subject areas

Pharmacology (medical)
Toxicology

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Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats. / Madeddu, P.; Glorioso, N.; Pinna Parpaglia, P.; Demontis, M. P.; Varoni, M. V.; Fattaccio, M. C.; Sabino, G.; Pisanu, G.; Patteri, G.; Anania, V.

In: Agents and Actions, Vol. 38, No. SUPPL. III, 1992, p. 156-162.

Research output: Contribution to journal › Article › peer-review

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title = "Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats",

abstract = "Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.",

author = "P. Madeddu and N. Glorioso and {Pinna Parpaglia}, P. and Demontis, {M. P.} and Varoni, {M. V.} and Fattaccio, {M. C.} and G. Sabino and G. Pisanu and G. Patteri and V. Anania",

year = "1992",

language = "English",

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T1 - Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats

AU - Madeddu, P.

AU - Glorioso, N.

AU - Pinna Parpaglia, P.

AU - Demontis, M. P.

AU - Varoni, M. V.

AU - Fattaccio, M. C.

AU - Sabino, G.

AU - Pisanu, G.

AU - Patteri, G.

AU - Anania, V.

PY - 1992

Y1 - 1992

N2 - Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.

AB - Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.

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Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats

Abstract

ASJC Scopus subject areas

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