Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats

P. Madeddu, N. Glorioso, P. Pinna Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, G. Sabino, G. Pisanu, G. Patteri, V. Anania

Research output: Contribution to journalArticlepeer-review

Abstract

Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 ± 0.6; furosemide: 42.4 ± 2.6 ml/8h, p <0.01) and urinary sodium excretion (vehicle: 0.9 ± 0.1; furosemide: 5.0 ± 0.4 mM/8h, p <0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 ± 4 to 113 ± 3 mmHg, p <0.01) and renal vascular resistances (from 15.6 ± 0.6 to 14.3 ± 0.7 RU, p <0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalAgents and Actions
Volume38
Issue numberSUPPL. III
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Fingerprint Dive into the research topics of 'Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats'. Together they form a unique fingerprint.

Cite this