KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with all

Lena Oevermann, Sebastian U. Michaelis, Markus Mezger, Peter Lang, Jacek Toporski, Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, Rupert Handgretinger

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.

Original languageEnglish
Pages (from-to)2744-2747
Number of pages4
JournalBlood
Volume124
Issue number17
DOIs
Publication statusPublished - Oct 23 2014

Fingerprint

KIR Receptors
Haplotypes
Transplantation
Tissue Donors
Recurrence
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disease-Free Survival
Genes
Donor Selection
T-cells
HLA Antigens
Stem cells
Blood

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology
  • Medicine(all)

Cite this

Oevermann, L., Michaelis, S. U., Mezger, M., Lang, P., Toporski, J., Bertaina, A., ... Handgretinger, R. (2014). KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with all. Blood, 124(17), 2744-2747. https://doi.org/10.1182/blood-2014-03-565069

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with all. / Oevermann, Lena; Michaelis, Sebastian U.; Mezger, Markus; Lang, Peter; Toporski, Jacek; Bertaina, Alice; Zecca, Marco; Moretta, Lorenzo; Locatelli, Franco; Handgretinger, Rupert.

In: Blood, Vol. 124, No. 17, 23.10.2014, p. 2744-2747.

Research output: Contribution to journalArticle

Oevermann, Lena ; Michaelis, Sebastian U. ; Mezger, Markus ; Lang, Peter ; Toporski, Jacek ; Bertaina, Alice ; Zecca, Marco ; Moretta, Lorenzo ; Locatelli, Franco ; Handgretinger, Rupert. / KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with all. In: Blood. 2014 ; Vol. 124, No. 17. pp. 2744-2747.
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AU - Bertaina, Alice

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