TY - JOUR
T1 - KIR/HLA combination associated with the risk of complications in celiac disease
AU - Caggiari, Laura
AU - Toffoli, Giuseppe
AU - de Re, Valli
AU - Orzes, Nicoletta
AU - Spina, Michele
AU - de Zorzi, Mariangela
AU - Maiero, Stefania
AU - Cannizzaro, Renato
AU - Canzonieri, Vincenzo
PY - 2011/10
Y1 - 2011/10
N2 - The pathogenesis of celiac disease (CD) is associated with polymorphisms in human leukocyte antigen (HLA) genes; however, compelling evidence suggests that additional non-HLA genes are associated with CD and related complications. The present study investigated whether killer cell immunoglobulin-like receptor (KIR)/HLA gene combinations are associated with CD and its clinical complications in the population of northeast Italy. The study included 61 adults affected by CD: 48 patients were at first diagnosis and 13 patients had CD-related complications (8 with refractory CD and 5 with cancer). Controls were 69 blood donors genotyped for KIR and HLA. Several statistically significant differences emerged between CD patients and blood donors. The results herein presented show that susceptibility to CD with refractory disease or cancer is associated with various genotypes including the 2DS2/2DL2+C1, 2DS3, 3DL1, and 2DL5B genes. In addition, the absence of the Bw4 ligand may be a predisposing factor for cancer. These results suggest that a KIR haplotype and HLA ligands may be involved in the susceptibility to important clinical CD complications such as tumors or refractoriness as a result of a gluten-free diet.
AB - The pathogenesis of celiac disease (CD) is associated with polymorphisms in human leukocyte antigen (HLA) genes; however, compelling evidence suggests that additional non-HLA genes are associated with CD and related complications. The present study investigated whether killer cell immunoglobulin-like receptor (KIR)/HLA gene combinations are associated with CD and its clinical complications in the population of northeast Italy. The study included 61 adults affected by CD: 48 patients were at first diagnosis and 13 patients had CD-related complications (8 with refractory CD and 5 with cancer). Controls were 69 blood donors genotyped for KIR and HLA. Several statistically significant differences emerged between CD patients and blood donors. The results herein presented show that susceptibility to CD with refractory disease or cancer is associated with various genotypes including the 2DS2/2DL2+C1, 2DS3, 3DL1, and 2DL5B genes. In addition, the absence of the Bw4 ligand may be a predisposing factor for cancer. These results suggest that a KIR haplotype and HLA ligands may be involved in the susceptibility to important clinical CD complications such as tumors or refractoriness as a result of a gluten-free diet.
KW - Autoimmunity
KW - Celiac disease
KW - Enteropathy-associated t-cell lymphoma
KW - HLA
KW - KIR
KW - MHC
KW - Molecular immunology
UR - http://www.scopus.com/inward/record.url?scp=84555203858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84555203858&partnerID=8YFLogxK
U2 - 10.5301/JBM.2011.8903
DO - 10.5301/JBM.2011.8903
M3 - Article
C2 - 22180175
AN - SCOPUS:84555203858
VL - 26
SP - 221
EP - 228
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
SN - 0393-6155
IS - 4
ER -