TY - JOUR
T1 - KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis
AU - Fusco, Caterina
AU - Guerini, Franca Rosa
AU - Nocera, Giustina
AU - Ventrella, Gianluca
AU - Caputo, Domenico
AU - Valentino, Maria Antonietta
AU - Agliardi, Cristina
AU - Gallotti, Jacopo
AU - Morra, Vincenzo Brescia
AU - Florio, Ciro
AU - Clerici, Mario
AU - Lombardi, Maria Luisa
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.
AB - Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.
KW - HLA-KIR ligands
KW - KIRs
KW - Multiple sclerosis
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U2 - 10.1016/j.jneuroim.2010.08.004
DO - 10.1016/j.jneuroim.2010.08.004
M3 - Article
C2 - 20826009
AN - SCOPUS:78650226799
VL - 229
SP - 232
EP - 237
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -