KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

Caterina Fusco, Franca Rosa Guerini, Giustina Nocera, Gianluca Ventrella, Domenico Caputo, Maria Antonietta Valentino, Cristina Agliardi, Jacopo Gallotti, Vincenzo Brescia Morra, Ciro Florio, Mario Clerici, Maria Luisa Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Neuroimmunology
Volume229
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2010

Keywords

  • HLA-KIR ligands
  • KIRs
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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