KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

Caterina Fusco; Franca Rosa Guerini; Giustina Nocera; Gianluca Ventrella; Domenico Caputo; Maria Antonietta Valentino; Cristina Agliardi; Jacopo Gallotti; Vincenzo Brescia Morra; Ciro Florio; Mario Clerici; Maria Luisa Lombardi

doi:10.1016/j.jneuroim.2010.08.004

KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

Caterina Fusco, Franca Rosa Guerini, Giustina Nocera, Gianluca Ventrella, Domenico Caputo, Maria Antonietta Valentino, Cristina Agliardi, Jacopo Gallotti, Vincenzo Brescia Morra, Ciro Florio, Mario Clerici, Maria Luisa Lombardi

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p_y=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p_y=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.

Original language	English
Pages (from-to)	232-237
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	229
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.08.004
Publication status	Published - Dec 15 2010

Keywords

HLA-KIR ligands
KIRs
Multiple sclerosis

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

Access to Document

10.1016/j.jneuroim.2010.08.004

Cite this

@article{904a1208c14840d28a93ba5fad44a569,

title = "KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis",

abstract = "Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.",

keywords = "HLA-KIR ligands, KIRs, Multiple sclerosis",

author = "Caterina Fusco and Guerini, {Franca Rosa} and Giustina Nocera and Gianluca Ventrella and Domenico Caputo and Valentino, {Maria Antonietta} and Cristina Agliardi and Jacopo Gallotti and Morra, {Vincenzo Brescia} and Ciro Florio and Mario Clerici and Lombardi, {Maria Luisa}",

year = "2010",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2010.08.004",

language = "English",

volume = "229",

pages = "232--237",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier Science B.V.",

number = "1-2",

}

TY - JOUR

T1 - KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

AU - Fusco, Caterina

AU - Guerini, Franca Rosa

AU - Nocera, Giustina

AU - Ventrella, Gianluca

AU - Caputo, Domenico

AU - Valentino, Maria Antonietta

AU - Agliardi, Cristina

AU - Gallotti, Jacopo

AU - Morra, Vincenzo Brescia

AU - Florio, Ciro

AU - Clerici, Mario

AU - Lombardi, Maria Luisa

PY - 2010/12/15

Y1 - 2010/12/15

N2 - Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.

AB - Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py=0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py=0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.

KW - HLA-KIR ligands

KW - KIRs

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=78650226799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650226799&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2010.08.004

DO - 10.1016/j.jneuroim.2010.08.004

M3 - Article

C2 - 20826009

AN - SCOPUS:78650226799

VL - 229

SP - 232

EP - 237

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this