The Klinefelter syndrome (KS) is characterized by a 47, XXY karyotype resulting in primary hypogonadism associated with mental retardation in 15 to 20% of cases. While abnormal EEGs were found in a large subset of patients, only 7 cases of KS associated with epilepsy have been reported; the prevalence of epilepsy in KS patients is thought to be around 17%. Among 143 consecutive KS patients diagnosed at a mean age of 23 years, we found 7 cases with epilepsy (4,9%), among which 5 were followed at our center. The epilepsy was classified as situation-related seizures (n = 1), generalized idiopathic (n = 2) and partial cryptogenic (n = 2). The additional X chromosome may be implied in the occurrence of epilepsy.
|Translated title of the contribution||Klinefelter syndrome and epilepsy: 5 Cases|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Clinical Neurology