Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders

A E Calogero, V A Giagulli, L M Mongioì, V Triggiani, A F Radicioni, E A Jannini, D Pasquali, Klinefelter ItaliaN Group (KING)

Research output: Contribution to journalReview articlepeer-review

Abstract

Klinefelter syndrome (KS) is one of the most common genetic causes of male infertility. This condition is associated with much comorbidity and with a lower life expectancy. The aim of this review is to explore more in depth cardiovascular and metabolic disorders associated to KS. KS patients have an increased risk of cerebrovascular disease (standardized mortality ratio, SMR, 2.2; 95% confidence interval, CI, 1.6-3.0), but it is not clear whether the cause of the death is of thrombotic or hemorrhagic nature. Cardiovascular congenital anomalies (SMR, 7.3; 95% CI, 2.4-17.1) and the development of thrombosis or leg ulcers (SMR, 7.9; 95% CI, 2.9-17.2) are also more frequent in these subjects. Moreover, cardiovascular abnormalities may be at least partially reversed by testosterone replacement therapy (TRT). KS patients have also an increased probability of endocrine and/or metabolic disease, especially obesity, metabolic syndrome and type 2 diabetes mellitus. The effects of TRT on these abnormalities are not entirely clear.

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalJournal of Endocrinological Investigation
Volume40
Issue number7
DOIs
Publication statusPublished - Jul 2017
Externally publishedYes

Keywords

  • Journal Article
  • Review

Fingerprint Dive into the research topics of 'Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders'. Together they form a unique fingerprint.

Cite this