Klotho at the Edge of Alzheimer’s Disease and Senile Depression

Research output: Contribution to journalArticlepeer-review


Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases. Alterations of this protein seem to influence the development of serotonergic neurons and could play a role in major depression in the elderly. Pretreatment of neurons with Klotho protein can avoid neuronal injury related to the toxic amyloid-β and glutamate, centrally related to the pathogenesis of Alzheimer’s disease (AD), in order that Klotho protein could play a neuroprotective role in AD patients. Late-life depression, mild cognitive impairment, and dementia are different nosological entities but share common neurobiological facets and could represent a clinical continuum. Enhancement of Klotho levels in the early stages of the disease could represent a therapeutic strategy to prevent further deterioration and to ameliorate the outcome of elderly AD patients with or without major depression.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalMolecular Neurobiology
Publication statusAccepted/In press - Jul 5 2018


  • Aging
  • Alzheimer’s disease
  • Depression
  • KL
  • Klotho
  • Late-life major depressive disorder
  • MDD

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience


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