Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder

Giulia Paroni, Davide Seripa, Andrea Fontana, Grazia D’Onofrio, Carolina Gravina, Maria Urbano, Filomena Addante, Madia Lozupone, Massimiliano Copetti, Alberto Pilotto, Antonio Greco, Francesco Panza

Research output: Contribution to journalArticlepeer-review

Abstract

Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the response to treatment with selective serotonin reuptake inhibitors (SSRIs) in late-life depressive syndromes and late-life major depressive disorder (MDD) is unclear. We genotyped three single-nucleotide polymorphisms (SNPs) of KL in 329 older patients with diagnosis of late-life MDD, treated with SSRIs and evaluated with the Hamilton Rating Scale for Depression 21-items (HRSD-21) at baseline and after 6 months. A reduction ≥50 and

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalMolecular Neurobiology
DOIs
Publication statusAccepted/In press - Feb 3 2016

Keywords

  • Klotho
  • Late-life depression
  • Late-life major depressive disorder
  • Older age
  • Response to treatment
  • Selective serotonin reuptake inhibitors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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