Knowledge, attitudes and behavior of physicians regarding predictive genetic tests for breast and colorectal cancer

Carolina Marzuillo, Corrado De Vito, Stefania Boccia, Maddalena D'Addario, Elvira D'Andrea, Paola Santini, Antonio Boccia, Paolo Villari

Research output: Contribution to journalArticle

Abstract

Background: Genetic testing for cancer susceptibility is an emerging technology in medicine. This study assessed the knowledge, attitudes and professional behavior of Italian physicians regarding the use of predictive genetic tests for breast and colorectal cancer, including the BRCA1/2 and APC tests. Methods: A cross-sectional survey of a random sample of Italian physicians was performed in 2010 through a self-administered questionnaire. Results: A response rate of 69.6% (1079 questionnaires) was achieved. A significant lack of knowledge was detected, particularly for APC testing. Less than half of the physicians agreed on the importance of efficacy and cost-effectiveness evidence in the selection of predictive genetic tests to be offered to the patients. Multiple logistic regression analyses showed that education had a positive influence on knowledge, attitudes and, to a lesser extent, professional use. The factor most strongly related to the physicians' use of genetic testing was patients requests for breast (odds ratio = 12.65; 95% confidence interval 7.77-20.59) or colorectal cancer tests (odds ratio = 7.02; 95% confidence interval 3.61-13.64). A high level of interest for specific training was reported by almost all physicians surveyed. Conclusions: Targeted educational programs are needed to improve the expertise of physicians, and, ultimately, to enhance the appropriate use of genetic tests in clinical practice.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalPreventive Medicine
Volume57
Issue number5
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Colorectal Neoplasms
Breast Neoplasms
Physicians
Genetic Testing
Odds Ratio
Confidence Intervals
Cost-Benefit Analysis
Breast
Cross-Sectional Studies
Logistic Models
Regression Analysis
Medicine
Technology
Education
Neoplasms
Surveys and Questionnaires

Keywords

  • Attitudes
  • Cancer predictive genetic tests
  • Cross-sectional survey
  • Knowledge
  • Physicians
  • Professional behavior

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Knowledge, attitudes and behavior of physicians regarding predictive genetic tests for breast and colorectal cancer. / Marzuillo, Carolina; De Vito, Corrado; Boccia, Stefania; D'Addario, Maddalena; D'Andrea, Elvira; Santini, Paola; Boccia, Antonio; Villari, Paolo.

In: Preventive Medicine, Vol. 57, No. 5, 11.2013, p. 477-482.

Research output: Contribution to journalArticle

Marzuillo, C, De Vito, C, Boccia, S, D'Addario, M, D'Andrea, E, Santini, P, Boccia, A & Villari, P 2013, 'Knowledge, attitudes and behavior of physicians regarding predictive genetic tests for breast and colorectal cancer', Preventive Medicine, vol. 57, no. 5, pp. 477-482. https://doi.org/10.1016/j.ypmed.2013.06.022
Marzuillo, Carolina ; De Vito, Corrado ; Boccia, Stefania ; D'Addario, Maddalena ; D'Andrea, Elvira ; Santini, Paola ; Boccia, Antonio ; Villari, Paolo. / Knowledge, attitudes and behavior of physicians regarding predictive genetic tests for breast and colorectal cancer. In: Preventive Medicine. 2013 ; Vol. 57, No. 5. pp. 477-482.
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