KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

A. Baraniak, R. Izdebski, J. Fiett, M. Herda, L. P G Derde, M. J M Bonten, A. Adler, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, Marek Gniadkowski, MOSAR WP2, WP3, and WP5 Study Groups, Angelo Rossini, Antonino Salvia

Research output: Contribution to journalArticlepeer-review


In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.

Original languageEnglish
Pages (from-to)1912-7
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Issue number3
Publication statusPublished - 2016


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Citrobacter freundii
  • DNA Transposable Elements
  • Enterobacteriaceae Infections
  • Escherichia coli
  • Europe
  • Humans
  • Israel
  • Klebsiella pneumoniae
  • Plasmids
  • beta-Lactamases
  • Journal Article
  • Research Support, Non-U.S. Gov't


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