KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

A. Baraniak; R. Izdebski; J. Fiett; M. Herda; L. P G Derde; M. J M Bonten; A. Adler; Y. Carmeli; H. Goossens; W. Hryniewicz; C. Brun-Buisson; Marek Gniadkowski; MOSAR WP2, WP3, and WP5 Study Groups; Angelo Rossini; Antonino Salvia

doi:10.1128/AAC.02756-15

KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

A. Baraniak, R. Izdebski, J. Fiett, M. Herda, L. P G Derde, M. J M Bonten, A. Adler, Y. Carmeli, H. Goossens, W. Hryniewicz, C. Brun-Buisson, Marek Gniadkowski, MOSAR WP2, WP3, and WP5 Study Groups, Angelo Rossini, Antonino Salvia

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.

Original language	English
Pages (from-to)	1912-7
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	3
DOIs	https://doi.org/10.1128/AAC.02756-15
Publication status	Published - 2016

Keywords

Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
Citrobacter freundii
DNA Transposable Elements
Enterobacteriaceae Infections
Escherichia coli
Europe
Humans
Israel
Klebsiella pneumoniae
Plasmids
beta-Lactamases
Journal Article
Research Support, Non-U.S. Gov't

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10.1128/AAC.02756-15

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Baraniak, A., Izdebski, R., Fiett, J., Herda, M., Derde, L. P. G., Bonten, M. J. M., Adler, A., Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-Buisson, C., Gniadkowski, M., MOSAR WP2, WP3, and WP5 Study Groups, Rossini, A., & Salvia, A. (2016). KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel. Antimicrobial Agents and Chemotherapy, 60(3), 1912-7. https://doi.org/10.1128/AAC.02756-15

KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel. / Baraniak, A.; Izdebski, R.; Fiett, J.; Herda, M.; Derde, L. P G; Bonten, M. J M; Adler, A.; Carmeli, Y.; Goossens, H.; Hryniewicz, W.; Brun-Buisson, C.; Gniadkowski, Marek; MOSAR WP2, WP3, and WP5 Study Groups ; Rossini, Angelo ; Salvia, Antonino.

In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 3, 2016, p. 1912-7.

Research output: Contribution to journal › Article › peer-review

Baraniak, A, Izdebski, R, Fiett, J, Herda, M, Derde, LPG, Bonten, MJM, Adler, A, Carmeli, Y, Goossens, H, Hryniewicz, W, Brun-Buisson, C, Gniadkowski, M, MOSAR WP2, WP3, and WP5 Study Groups, Rossini, A & Salvia, A 2016, 'KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel', Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1912-7. https://doi.org/10.1128/AAC.02756-15

Baraniak, A. ; Izdebski, R. ; Fiett, J. ; Herda, M. ; Derde, L. P G ; Bonten, M. J M ; Adler, A. ; Carmeli, Y. ; Goossens, H. ; Hryniewicz, W. ; Brun-Buisson, C. ; Gniadkowski, Marek ; MOSAR WP2, WP3, and WP5 Study Groups ; Rossini, Angelo ; Salvia, Antonino. / KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel. In: Antimicrobial Agents and Chemotherapy. 2016 ; Vol. 60, No. 3. pp. 1912-7.

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title = "KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel",

abstract = "In a 2008-2011 survey, 17,945 patients in 18 hospital units in Europe and Israel were screened for carriage of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, resulting in identification of 124 positive patients. The isolates were dominated by Klebsiella pneumoniae sequence type 258 (ST258) KPC-2 and ST512 KPC-3, mainly from Greece and Italy, respectively, whereas Israeli isolates were of diverse species, clones, and KPC variants. Various blaKPC platforms were observed, among which IncFIIK-FIBK plasmids with blaKPC-2/-3 genes in the Tn4401a transposon prevailed.",

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KW - Bacterial Proteins

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KW - Citrobacter freundii

KW - DNA Transposable Elements

KW - Enterobacteriaceae Infections

KW - Escherichia coli

KW - Europe

KW - Humans

KW - Israel

KW - Klebsiella pneumoniae

KW - Plasmids

KW - beta-Lactamases

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JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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ER -

KPC-Like Carbapenemase-Producing Enterobacteriaceae Colonizing Patients in Europe and Israel

Abstract

Keywords

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