KSRP, many functions for a single protein

Paola Briata, Ching Yi Chen, Matteo Giovarelli, Michela Pasero, Michele Trabucchi, Andres Ramos, Roberto Gherzi

Research output: Contribution to journalArticle

Abstract

KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of posttranslational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.

Original languageEnglish
Pages (from-to)1787-1796
Number of pages10
JournalFrontiers in Bioscience
Volume16
Issue number5
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • AUrich elements
  • KH-domain
  • microRNA
  • mRNA decay
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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