KSRP promotes the maturation of a group of miRNA precuresors

Michele Trabucchi, Paola Briata, Witold Filipowicz, Andres Ramos, Roberto Gherzi, Michael G. Rosenfeld

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

microrNNA (mirNAs) are small noncoding RNAs that down-regulate gene expression by reducing stability and/or translation of target mRNAs. In animals, miRNAs arise from sequential processing of hairpin primary transcripts by two rNase III domain-containing enzymes, namely Drosha and Dicer, to generate a mature form of about 22 nucleotides. In this chapter we discuss our latest fndings indicating that KSRP is an integral component of both Drosha and Dicer complexes. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation. our data indicate that the terminal loop is a pivotal structure where activators of miRNA processing as well as repressors of miRNA processing act in a coordinated way to convert cellular signals into changes in miRNA expression processing. This uncovers a new level of complexity of miRNA mechanisms for gene expression regulation.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages36-42
Number of pages7
Volume700
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume700
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Trabucchi, M., Briata, P., Filipowicz, W., Ramos, A., Gherzi, R., & Rosenfeld, M. G. (2010). KSRP promotes the maturation of a group of miRNA precuresors. In Advances in Experimental Medicine and Biology (Vol. 700, pp. 36-42). (Advances in Experimental Medicine and Biology; Vol. 700). https://doi.org/10.1007/978-1-4419-7823-3_4