Abstract
Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.
Original language | English |
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Pages (from-to) | 51-57 |
Number of pages | 7 |
Journal | Journal of the Neurological Sciences |
Volume | 99 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1990 |
Keywords
- Excitotoxins
- Glioma
- Kynurenic acid
- Kynurenines
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology