Kynurenic acid synthesis by human glioma

Annamaria Vezzani; Jan Bert P Gramsbergen; Pietro Versari; Maria Antonietta Stasi; Francesco Procaccio; Robert Schwarcz

doi:10.1016/0022-510X(90)90198-V

Kynurenic acid synthesis by human glioma

Annamaria Vezzani, Jan Bert P Gramsbergen, Pietro Versari, Maria Antonietta Stasi, Francesco Procaccio, Robert Schwarcz

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Journal of the Neurological Sciences
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/0022-510X(90)90198-V
Publication status	Published - 1990

Keywords

Excitotoxins
Glioma
Kynurenic acid
Kynurenines

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Neuroscience(all)
Developmental Neuroscience
Neurology

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10.1016/0022-510X(90)90198-V

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title = "Kynurenic acid synthesis by human glioma",

abstract = "Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.",

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T1 - Kynurenic acid synthesis by human glioma

AU - Vezzani, Annamaria

AU - Gramsbergen, Jan Bert P

AU - Versari, Pietro

AU - Stasi, Maria Antonietta

AU - Procaccio, Francesco

AU - Schwarcz, Robert

PY - 1990

Y1 - 1990

N2 - Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.

AB - Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.

KW - Excitotoxins

KW - Glioma

KW - Kynurenic acid

KW - Kynurenines

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Kynurenic acid synthesis by human glioma

Abstract

Keywords

ASJC Scopus subject areas

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