Kynurenic acid synthesis by human glioma

Annamaria Vezzani, Jan Bert P Gramsbergen, Pietro Versari, Maria Antonietta Stasi, Francesco Procaccio, Robert Schwarcz

Research output: Contribution to journalArticlepeer-review

Abstract

Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 μM l-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalJournal of the Neurological Sciences
Volume99
Issue number1
DOIs
Publication statusPublished - 1990

Keywords

  • Excitotoxins
  • Glioma
  • Kynurenic acid
  • Kynurenines

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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