L-2-hydroxyglutaric aciduria and brain malignant tumors: A predisposing condition?

I. Moroni, M. Bugiani, L. D'Incerti, C. Maccagnano, M. Rimoldi, L. Bissola, B. Pollo, G. Finocchiaro, Graziella Uziel

Research output: Contribution to journalArticlepeer-review


L-2-hydroxyglutaric aciduria is a rare metabolic encephalopathy displaying a subcortical leukoencephalopathy on MRI. Diagnosis rests on detection of an abnormal accumulation of L-2-hydroxyglutaric acid in body fluids. The authors report on four patients who developed a malignant brain tumor during the course of the disease. This association points to a possible role of L-2-hydroxyglutaric aciduria in predisposing to brain tumorigenesis.

Original languageEnglish
Pages (from-to)1882-1884
Number of pages3
Issue number10
Publication statusPublished - May 25 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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