L-2-hydroxyglutaric aciduria and brain malignant tumors

A predisposing condition?

I. Moroni, M. Bugiani, L. D'Incerti, C. Maccagnano, M. Rimoldi, L. Bissola, B. Pollo, G. Finocchiaro, Graziella Uziel

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

L-2-hydroxyglutaric aciduria is a rare metabolic encephalopathy displaying a subcortical leukoencephalopathy on MRI. Diagnosis rests on detection of an abnormal accumulation of L-2-hydroxyglutaric acid in body fluids. The authors report on four patients who developed a malignant brain tumor during the course of the disease. This association points to a possible role of L-2-hydroxyglutaric aciduria in predisposing to brain tumorigenesis.

Original languageEnglish
Pages (from-to)1882-1884
Number of pages3
JournalNeurology
Volume62
Issue number10
Publication statusPublished - May 25 2004

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Brain Neoplasms
Metabolic Brain Diseases
Vascular Dementia
Body Fluids
Carcinogenesis
Brain
2-Hydroxyglutaricaciduria
alpha-hydroxyglutarate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

L-2-hydroxyglutaric aciduria and brain malignant tumors : A predisposing condition? / Moroni, I.; Bugiani, M.; D'Incerti, L.; Maccagnano, C.; Rimoldi, M.; Bissola, L.; Pollo, B.; Finocchiaro, G.; Uziel, Graziella.

In: Neurology, Vol. 62, No. 10, 25.05.2004, p. 1882-1884.

Research output: Contribution to journalArticle

Moroni, I. ; Bugiani, M. ; D'Incerti, L. ; Maccagnano, C. ; Rimoldi, M. ; Bissola, L. ; Pollo, B. ; Finocchiaro, G. ; Uziel, Graziella. / L-2-hydroxyglutaric aciduria and brain malignant tumors : A predisposing condition?. In: Neurology. 2004 ; Vol. 62, No. 10. pp. 1882-1884.
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