L-2-Hydroxyglutaric aciduria: MRI in seven cases

L. D'Incerti, L. Farina, I. Moroni, G. Uziel, M. Savoiardo

Research output: Contribution to journalArticlepeer-review


The MRI findings in 7 patients with L-2-Hydroxyglutaric aciduria (L-2-OHG aciduria) are described and compared with previous neuroradiological reports and the only three published pathological cases. Signal abnormalities involved peripheral subcortical while matter, basal ganglia and dentate nuclei. Cerebellar atrophy was present. Although similar appearances may be seen in other metabolic disorders, the distribution of signal abnormalities in L-2-OHG aciduria is highly characteristic and may suggest the correct diagnosis.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
Issue number11
Publication statusPublished - 1998


  • Brain, magnetic resonance imaging
  • L-2-Hydroxyglutaric aciduria

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology


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