L-Acetylcarnitine: A proposed therapeutic agent for painful peripheral neuropathies

S. Chiechio, A. Copani, F. Nicoletti, Robert W. Gereau

Research output: Contribution to journalArticlepeer-review


During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of L-acetylcarnitine as tested in clinical studies and in animal models of nerve injury.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalCurrent Neuropharmacology
Issue number3
Publication statusPublished - Jul 2006


  • Antinociception
  • L-acetylcarnitine
  • Neuropathic pain
  • Peripheral neuropathies

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Pharmacology


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