L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis

Valerio Pascale, Walter Pascale, Vito Lavanga, Valerio Sansone, Paolo Ferrario, Vito De Gennaro Colonna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P

Original languageEnglish
Pages (from-to)1057-1062
Number of pages6
JournalMedical Science Monitor
Volume19
DOIs
Publication statusPublished - Nov 26 2013

Keywords

  • Asymmetric dimethylarginine
  • Nitric oxide
  • Osteoarthritis

ASJC Scopus subject areas

  • Medicine(all)

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