L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis

Valerio Pascale; Walter Pascale; Vito Lavanga; Valerio Sansone; Paolo Ferrario; Vito De Gennaro Colonna

doi:10.12659/MSM.889275

L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis

Valerio Pascale, Walter Pascale, Vito Lavanga, Valerio Sansone, Paolo Ferrario, Vito De Gennaro Colonna

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P

Original language	English
Pages (from-to)	1057-1062
Number of pages	6
Journal	Medical Science Monitor
Volume	19
DOIs	https://doi.org/10.12659/MSM.889275
Publication status	Published - Nov 26 2013

Keywords

Asymmetric dimethylarginine
Nitric oxide
Osteoarthritis

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.12659/MSM.889275

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L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis. / Pascale, Valerio; Pascale, Walter; Lavanga, Vito; Sansone, Valerio; Ferrario, Paolo; Colonna, Vito De Gennaro.

In: Medical Science Monitor, Vol. 19, 26.11.2013, p. 1057-1062.

Research output: Contribution to journal › Article › peer-review

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AU - Ferrario, Paolo

AU - Colonna, Vito De Gennaro

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