Abstract
Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P
| Original language | English |
|---|---|
| Pages (from-to) | 1057-1062 |
| Number of pages | 6 |
| Journal | Medical Science Monitor |
| Volume | 19 |
| DOIs | |
| Publication status | Published - Nov 26 2013 |
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Keywords
- Asymmetric dimethylarginine
- Nitric oxide
- Osteoarthritis
ASJC Scopus subject areas
- Medicine(all)
Cite this
L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis. / Pascale, Valerio; Pascale, Walter; Lavanga, Vito; Sansone, Valerio; Ferrario, Paolo; Colonna, Vito De Gennaro.
In: Medical Science Monitor, Vol. 19, 26.11.2013, p. 1057-1062.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis
AU - Pascale, Valerio
AU - Pascale, Walter
AU - Lavanga, Vito
AU - Sansone, Valerio
AU - Ferrario, Paolo
AU - Colonna, Vito De Gennaro
PY - 2013/11/26
Y1 - 2013/11/26
N2 - Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P
AB - Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P
KW - Asymmetric dimethylarginine
KW - Nitric oxide
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84888340311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888340311&partnerID=8YFLogxK
U2 - 10.12659/MSM.889275
DO - 10.12659/MSM.889275
M3 - Article
VL - 19
SP - 1057
EP - 1062
JO - Medical Science Monitor
JF - Medical Science Monitor
SN - 1234-1010
ER -