Abstract
Background: The aim of this study was to investigate the involvement of the nitric oxide (NO) pathway in osteoarthritis (OA). Material/Methods: The study groups consisted of 32 patients with knee OA and 31 healthy controls. In peripheral venous blood samples (from the OA patients and the controls) and in synovial fluid samples (from the OA patients), the concentrations of L-arginine (ARN), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were evaluated. In plasma samples, thiobarbituric acid reactive substances (TBARS) were also measured. Results: Plasma ARN concentrations were lower in the OA patients than in controls (53.55±16.37 vs. 70.20±25.68 μmol/l) (P
Original language | English |
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Pages (from-to) | 1057-1062 |
Number of pages | 6 |
Journal | Medical Science Monitor |
Volume | 19 |
DOIs | |
Publication status | Published - Nov 26 2013 |
Keywords
- Asymmetric dimethylarginine
- Nitric oxide
- Osteoarthritis
ASJC Scopus subject areas
- Medicine(all)