L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction

X. Z. Zhang, G. Ardissino, L. Ghio, A. S. Tirelli, V. Daccò, D. Colombo, E. Pace, S. Testa, A. Claris-Appiani

Research output: Contribution to journalArticle

Abstract

Aims. L-arginine (LA), the precursor of nitric oxide (NO), was suggested to be beneficial in many forms of renal disease: hypertension, ureteral obstructive nephropathy and cyclosporin A (CsA) nephro-toxicity. Methods: Thus, we investigated the effects of LA supplementation on renal function, proteinuria and blood pressure (BP) in young renal allograft recipients with chronic renal transplant dysfunction treated with CsA. Eleven CsA-treated renal allograft recipients with chronic transplant dysfunction, aged 11 - 22 years, were randomly assigned to a 6-week treatment period with placebo (P), followed by 2 subsequent 6-week periods with LA supplementation (0.1 g/kg body weight/day) or a 6-week treatment period with LA, followed by 2 subsequent 6-week periods with P. At the end of each treatment period 24-hour BP recordings were made, and GFR (Inutest), RPF (PAH clearance) and the urinary excretion of protein, albumin, nitrate, cGMP and urea were evaluated. Results. In comparison to placebo, LA treatment did not significantly change GFR, RPF, proteinuria and albuminuria, mean systolic or diastolic BP. The urinary excretion of urea and NO3 increased after LA supplementation (uUrea: LA 26.3 ± 4.6 compared to P 23.5 ± 4.7 g/day/1.73 m3, p <0.05, uNO3: LA 514 ± 152 compared to P 95 ± 41 mM/day/1.73 m3, p

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalClinical Nephrology
Volume55
Issue number6
Publication statusPublished - 2001

Keywords

  • Blood pressure
  • Cyclosporin A
  • L-arginine
  • Nitric oxide
  • Renal allograft recipients
  • Renal hemodynamics

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction'. Together they form a unique fingerprint.

  • Cite this