l-Arginine therapy in Raynaud's phenomenon?

Angelo Agostoni, Bianca Marasini, Maria Luisa Biondi, Cristina Bassani, Anna Cazzaniga, Bianca Bottasso, Massimo Cugno

Research output: Contribution to journalArticlepeer-review


Since l-Arginine is the substrate for nitric oxide synthesis by vascular endothelial cells the effects of l-arginine treatment on the digital vascular response to local stimuli were investigated in patients with primary or secondary Raynaud's phenomenon. After therapy, patients withu Raynaud's phenomenon secondary to systemic sclerosis showed: (1) higher digital vasodilation after local warming, (2) cold-induced digital vasodilation, and (3) increase of plasma levels of tissue-type plasminogen activator.

Original languageEnglish
Pages (from-to)202-203
Number of pages2
JournalInternational Journal of Clinical & Laboratory Research
Issue number2-4
Publication statusPublished - Jun 1992


  • l-Arginine
  • Raynaud's phenomenon
  • Strain-gauge plethysmography
  • Systemic sclerosis
  • Tissue-type plasminogen activator

ASJC Scopus subject areas

  • Clinical Biochemistry


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