Abstract
The changes in plasma levels of the vitamin K-dependent natural anticoagulants protein C (PC) and protein S (PS) and procoagulant factors II, IX and X were evaluated in 8 adult patients during treatment with L-asparaginase (L-ase i.v. 120,000 U/m2 over 10 days). PC anticoagulant activity and factor IX, X and II coagulant activity decreased proportionally to their half-lives to a nadir of 50-60% of pretreatment values after 2-5 L-ase infusions, suggesting that inhibition of protein synthesis rather than consumption is the main mechanism responsible for the observed changes. Free PS antigen levels declined at a rate similar to total PS antigen, reaching a nadir of 56% of pretreatment values after 3 L-ase infusions; however, due to C4b-binding protein levels higher than total PS levels (p
| Original language | English |
|---|---|
| Pages (from-to) | 985-994 |
| Number of pages | 10 |
| Journal | Thrombosis Research |
| Volume | 59 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Sep 15 1990 |
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Keywords
- L-asparaginase
- protein C activity
- protein S activity
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology
Cite this
L-asparaginase treatment reduces the anticoagulant potential of the protein C system without affecting vitamin K-dependent carboxylation. / Vigano'D'Angelo, Silvana; Gugliotta, Luigi; Mattioli Belmonte, Monica; Cascione, Maria Loredana; Pattarini, Elisabetta; D'Angelo, Armando.
In: Thrombosis Research, Vol. 59, No. 6, 15.09.1990, p. 985-994.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - L-asparaginase treatment reduces the anticoagulant potential of the protein C system without affecting vitamin K-dependent carboxylation
AU - Vigano'D'Angelo, Silvana
AU - Gugliotta, Luigi
AU - Mattioli Belmonte, Monica
AU - Cascione, Maria Loredana
AU - Pattarini, Elisabetta
AU - D'Angelo, Armando
PY - 1990/9/15
Y1 - 1990/9/15
N2 - The changes in plasma levels of the vitamin K-dependent natural anticoagulants protein C (PC) and protein S (PS) and procoagulant factors II, IX and X were evaluated in 8 adult patients during treatment with L-asparaginase (L-ase i.v. 120,000 U/m2 over 10 days). PC anticoagulant activity and factor IX, X and II coagulant activity decreased proportionally to their half-lives to a nadir of 50-60% of pretreatment values after 2-5 L-ase infusions, suggesting that inhibition of protein synthesis rather than consumption is the main mechanism responsible for the observed changes. Free PS antigen levels declined at a rate similar to total PS antigen, reaching a nadir of 56% of pretreatment values after 3 L-ase infusions; however, due to C4b-binding protein levels higher than total PS levels (p
AB - The changes in plasma levels of the vitamin K-dependent natural anticoagulants protein C (PC) and protein S (PS) and procoagulant factors II, IX and X were evaluated in 8 adult patients during treatment with L-asparaginase (L-ase i.v. 120,000 U/m2 over 10 days). PC anticoagulant activity and factor IX, X and II coagulant activity decreased proportionally to their half-lives to a nadir of 50-60% of pretreatment values after 2-5 L-ase infusions, suggesting that inhibition of protein synthesis rather than consumption is the main mechanism responsible for the observed changes. Free PS antigen levels declined at a rate similar to total PS antigen, reaching a nadir of 56% of pretreatment values after 3 L-ase infusions; however, due to C4b-binding protein levels higher than total PS levels (p
KW - L-asparaginase
KW - protein C activity
KW - protein S activity
UR - http://www.scopus.com/inward/record.url?scp=0025130158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025130158&partnerID=8YFLogxK
U2 - 10.1016/0049-3848(90)90122-S
DO - 10.1016/0049-3848(90)90122-S
M3 - Article
C2 - 2148229
AN - SCOPUS:0025130158
VL - 59
SP - 985
EP - 994
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 6
ER -