L-asparaginase treatment reduces the anticoagulant potential of the protein C system without affecting vitamin K-dependent carboxylation

Silvana Vigano'D'Angelo, Luigi Gugliotta, Monica Mattioli Belmonte, Maria Loredana Cascione, Elisabetta Pattarini, Armando D'Angelo

Research output: Contribution to journalArticlepeer-review

Abstract

The changes in plasma levels of the vitamin K-dependent natural anticoagulants protein C (PC) and protein S (PS) and procoagulant factors II, IX and X were evaluated in 8 adult patients during treatment with L-asparaginase (L-ase i.v. 120,000 U/m2 over 10 days). PC anticoagulant activity and factor IX, X and II coagulant activity decreased proportionally to their half-lives to a nadir of 50-60% of pretreatment values after 2-5 L-ase infusions, suggesting that inhibition of protein synthesis rather than consumption is the main mechanism responsible for the observed changes. Free PS antigen levels declined at a rate similar to total PS antigen, reaching a nadir of 56% of pretreatment values after 3 L-ase infusions; however, due to C4b-binding protein levels higher than total PS levels (p

Original languageEnglish
Pages (from-to)985-994
Number of pages10
JournalThrombosis Research
Volume59
Issue number6
DOIs
Publication statusPublished - Sep 15 1990

Keywords

  • L-asparaginase
  • protein C activity
  • protein S activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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