L Dopa induced improvement of coma due to brain injury

C. Di Rocco, G. Maira, M. Meglio, G. F. Rossi

Research output: Contribution to journalArticle

Abstract

Fifteen patients in a comatose state of different degrees for at least 6 days, or presenting an apallic syndrome due to primary cerebral lesion, have been treated with L Dopa. The patients who began their treatment while in coma III, II and I underwent a gradual and progressive improvement of the level of consciousness as well as of the electroencephalographic activity. No clearcut results were obtained in the patients with an apallic syndrome. A direct relationship between L Dopa treatment and improvement of the state of consciousness is suggested by the following facts: the level of coma was stabilized for several days prior to the L Dopa treatment; a parallelism was observed between consciousness improvement and dose of the drug employed; the temporary suppression of L Dopa treatment was associated with deterioration of clinical conditions. The hypothesis of a role of a disturbance of the cerebral amine metabolism in the disorders of the state of consciousness following cerebral injury, and of a corrective effect of L Dopa on such a disturbance is discussed.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalActa Medica Romana
Volume11
Issue number5-6
Publication statusPublished - 1973

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Levodopa
Coma
Brain Injuries
Consciousness
Consciousness Disorders
Therapeutics
Amines
Wounds and Injuries
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Di Rocco, C., Maira, G., Meglio, M., & Rossi, G. F. (1973). L Dopa induced improvement of coma due to brain injury. Acta Medica Romana, 11(5-6), 313-319.

L Dopa induced improvement of coma due to brain injury. / Di Rocco, C.; Maira, G.; Meglio, M.; Rossi, G. F.

In: Acta Medica Romana, Vol. 11, No. 5-6, 1973, p. 313-319.

Research output: Contribution to journalArticle

Di Rocco, C, Maira, G, Meglio, M & Rossi, GF 1973, 'L Dopa induced improvement of coma due to brain injury', Acta Medica Romana, vol. 11, no. 5-6, pp. 313-319.
Di Rocco C, Maira G, Meglio M, Rossi GF. L Dopa induced improvement of coma due to brain injury. Acta Medica Romana. 1973;11(5-6):313-319.
Di Rocco, C. ; Maira, G. ; Meglio, M. ; Rossi, G. F. / L Dopa induced improvement of coma due to brain injury. In: Acta Medica Romana. 1973 ; Vol. 11, No. 5-6. pp. 313-319.
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