Abstract
Fifteen patients in a comatose state of different degrees for at least 6 days, or presenting an apallic syndrome due to primary cerebral lesion, have been treated with L Dopa. The patients who began their treatment while in coma III, II and I underwent a gradual and progressive improvement of the level of consciousness as well as of the electroencephalographic activity. No clearcut results were obtained in the patients with an apallic syndrome. A direct relationship between L Dopa treatment and improvement of the state of consciousness is suggested by the following facts: the level of coma was stabilized for several days prior to the L Dopa treatment; a parallelism was observed between consciousness improvement and dose of the drug employed; the temporary suppression of L Dopa treatment was associated with deterioration of clinical conditions. The hypothesis of a role of a disturbance of the cerebral amine metabolism in the disorders of the state of consciousness following cerebral injury, and of a corrective effect of L Dopa on such a disturbance is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 313-319 |
| Number of pages | 7 |
| Journal | Acta Medica Romana |
| Volume | 11 |
| Issue number | 5-6 |
| Publication status | Published - 1973 |
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L Dopa induced improvement of coma due to brain injury. / Di Rocco, C.; Maira, G.; Meglio, M.; Rossi, G. F.
In: Acta Medica Romana, Vol. 11, No. 5-6, 1973, p. 313-319.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - L Dopa induced improvement of coma due to brain injury
AU - Di Rocco, C.
AU - Maira, G.
AU - Meglio, M.
AU - Rossi, G. F.
PY - 1973
Y1 - 1973
N2 - Fifteen patients in a comatose state of different degrees for at least 6 days, or presenting an apallic syndrome due to primary cerebral lesion, have been treated with L Dopa. The patients who began their treatment while in coma III, II and I underwent a gradual and progressive improvement of the level of consciousness as well as of the electroencephalographic activity. No clearcut results were obtained in the patients with an apallic syndrome. A direct relationship between L Dopa treatment and improvement of the state of consciousness is suggested by the following facts: the level of coma was stabilized for several days prior to the L Dopa treatment; a parallelism was observed between consciousness improvement and dose of the drug employed; the temporary suppression of L Dopa treatment was associated with deterioration of clinical conditions. The hypothesis of a role of a disturbance of the cerebral amine metabolism in the disorders of the state of consciousness following cerebral injury, and of a corrective effect of L Dopa on such a disturbance is discussed.
AB - Fifteen patients in a comatose state of different degrees for at least 6 days, or presenting an apallic syndrome due to primary cerebral lesion, have been treated with L Dopa. The patients who began their treatment while in coma III, II and I underwent a gradual and progressive improvement of the level of consciousness as well as of the electroencephalographic activity. No clearcut results were obtained in the patients with an apallic syndrome. A direct relationship between L Dopa treatment and improvement of the state of consciousness is suggested by the following facts: the level of coma was stabilized for several days prior to the L Dopa treatment; a parallelism was observed between consciousness improvement and dose of the drug employed; the temporary suppression of L Dopa treatment was associated with deterioration of clinical conditions. The hypothesis of a role of a disturbance of the cerebral amine metabolism in the disorders of the state of consciousness following cerebral injury, and of a corrective effect of L Dopa on such a disturbance is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015706239&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 313
EP - 319
JO - Acta Medica Romana
JF - Acta Medica Romana
SN - 0001-6098
IS - 5-6
ER -