L-dopa modulates motor cortex excitability in Alzheimer's disease patients

Alessandro Martorana, Alessandro Stefani, Maria Giuseppina Palmieri, Zaira Esposito, Giorgio Bernardi, Giuseppe Sancesario, Mariangela Pierantozzi

Research output: Contribution to journalArticle

Abstract

In Alzheimer's disease (AD), transcranial magnetic stimulation (TMS) studies have shown abnormalities of motor cortical excitability, such as a decreased intra-cortical inhibition (ICI) and changes in resting motor threshold (rMT). We studied the effects of l-dopa on rMT and ICI in a cohort of moderate AD patients after paired-pulse TMS. Results were compared with a control group of healthy subjects. As expected, AD patients showed a significant reduction in ICI and a lower rMT. l-dopa administration (soluble form, melevodopa 200 mg) promptly reversed the ICI impairment up to normalization. This effect was specific, since it was not mimicked in control subjects. These results indicate a possible role of dopamine in modulating AD cortical excitability, thus suggesting an interaction between dopaminergic ascending pathways and endogenous intracortical transmitters. In addition, considering that l-dopa showed a pharmacological profile similar to the one of cholinomimetics, l-dopa might represent a reliable tool to study new therapeutic perspective and strategies for AD.

Original languageEnglish
Pages (from-to)1313-1319
Number of pages7
JournalJournal of Neural Transmission
Volume115
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Motor Cortex
Levodopa
Dihydroxyphenylalanine
Alzheimer Disease
Transcranial Magnetic Stimulation
Cholinergic Agents
Dopamine
Healthy Volunteers
Pharmacology
Control Groups
Inhibition (Psychology)
Cortical Excitability

Keywords

  • Acetylcholine
  • Alzheimer's disease
  • Intracortical inhibition
  • Levodopa
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Martorana, A., Stefani, A., Palmieri, M. G., Esposito, Z., Bernardi, G., Sancesario, G., & Pierantozzi, M. (2008). L-dopa modulates motor cortex excitability in Alzheimer's disease patients. Journal of Neural Transmission, 115(9), 1313-1319. https://doi.org/10.1007/s00702-008-0082-z

L-dopa modulates motor cortex excitability in Alzheimer's disease patients. / Martorana, Alessandro; Stefani, Alessandro; Palmieri, Maria Giuseppina; Esposito, Zaira; Bernardi, Giorgio; Sancesario, Giuseppe; Pierantozzi, Mariangela.

In: Journal of Neural Transmission, Vol. 115, No. 9, 09.2008, p. 1313-1319.

Research output: Contribution to journalArticle

Martorana, A, Stefani, A, Palmieri, MG, Esposito, Z, Bernardi, G, Sancesario, G & Pierantozzi, M 2008, 'L-dopa modulates motor cortex excitability in Alzheimer's disease patients', Journal of Neural Transmission, vol. 115, no. 9, pp. 1313-1319. https://doi.org/10.1007/s00702-008-0082-z
Martorana A, Stefani A, Palmieri MG, Esposito Z, Bernardi G, Sancesario G et al. L-dopa modulates motor cortex excitability in Alzheimer's disease patients. Journal of Neural Transmission. 2008 Sep;115(9):1313-1319. https://doi.org/10.1007/s00702-008-0082-z
Martorana, Alessandro ; Stefani, Alessandro ; Palmieri, Maria Giuseppina ; Esposito, Zaira ; Bernardi, Giorgio ; Sancesario, Giuseppe ; Pierantozzi, Mariangela. / L-dopa modulates motor cortex excitability in Alzheimer's disease patients. In: Journal of Neural Transmission. 2008 ; Vol. 115, No. 9. pp. 1313-1319.
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